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ISTN Nanotechnology Development. September 22, 2005. ISTN Inc. - An Introduction. A small Contract Research company of 15 employees, including 9 Ph. D. research scientists

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ISTN Nanotechnology Development

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Istn nanotechnology development

ISTN Nanotechnology Development

September 22, 2005


Istn inc an introduction

ISTN Inc. - An Introduction

  • A small Contract Research company of 15 employees, including 9 Ph. D. research scientists

  • Has superior knowledge and experience in water treatment, foaming insulation, adhesives, optical electronics, and biotechnology fields

  • Located in York, PA with office, laboratories, and many analytical instruments

  • Ongoing Joint-Venture and Projects in China, Taiwan, Korea, and other countries

  • Collaboration with many Universities and Institutes in the United States and overseas


Istn early mover in nanotechnology

ISTN – Early Mover in Nanotechnology

  • Founded in 1997 by Dr. Arthur J. Yang

    • Former Insulation Research Director at Armstrong

    • ATP grant for Nanopore Thermal Insulation – 1992

  • Develop organic-inorganic nanocomposites

    • Functionalized silica materials (sol-gel chemistry)

    • Polymer-metal composites

Industrial Products

Opto-Electronics

Biotechnology


Csmg nanopore reactive adsorbent

Selective Adsorption – significantly enhances reaction kinetics.

High Capacity –

nanopores, surface regeneration, selectivity

Flexible Platform –

surface ligand groups can be designed to accomplish variety of functions, (adsorption, separation, catalysis, etc.)

Integration –

adsorption, catalysis, and reaction combined in one product

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CSMG – Nanopore Reactive Adsorbent

Silica

Hg+2

Hg+2

Na+

Iron

Platform Technology with Tremendous Commercial Potential


Nanopore enhanced enzyme device

Nanopore Enhanced Enzyme Device

Key Properties

  • Immobilized enzyme can be reused many times

  • Reaction can occur in continuous flow mode instead of batch mode

  • Product can be separated from reactants during reaction, which promotes reaction rate

  • Reaction and separation done in one continuous flow operation

  • Column can be regenerated by effluent wash after saturation

  • Process is suitable for large-scale operation and can be fully automated

Encapsulation of Biological Entity With Silica


Optical coatings

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Optical Coatings

  • Wet chemistry process, no vacuum needed

  • Sol-gel process to prepare optical transparent coatings

  • Anti-glare/anti-reflective or high reflective coatings

  • Low cost process

  • Ready to apply to large surfaces

  • Application including: lenses, solar panel, display screens, architecture glasses, protection films, etc.


Nanotechnology for drug delivery

Nanotechnology for Drug Delivery

Collaboration with University of Michigan’s College of Pharmacy

  • Silica-Chitosan Composite

    • Funding: Phase I SBIR (2004)

    • Applying for Phase II

      Key Properties

    • Controlled release for ulcer treatment. Maximizes efficacy while minimizing side effects

    • Silica-Chitosan composite has increased residence time in stomach (highly acidic).

    • Entangled network of chitosan and silica molecules maintain structural integrity

  • Low MW Protamine (LMWP)

    • Funding: Phase I STTR, Phase II SBIR (2002)

    • Pursuing IND from FDA

      Key Properties

    • Drug use for non-toxic heparin neutralization which can also be used for drug and gene delivery

    • Able to translocate through cell membranes (structural similarities to HIV-TAT protein)

    • CSMG technology utalized to optimize thermolysin immobilization for continuous production of LMWP


Flexible commercialization strategy

Flexible Commercialization Strategy

Strategic Alliances

Licensing

New Company


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