Find and operational research in hiv associated tuberculosis
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FIND and Operational Research in HIV-Associated Tuberculosis. Rick O’Brien Foundation for Innovative New Diagnostics, Geneva. FIND was established in 2003 with a grant from the Bill and Melinda Gates Foundation FIND is based in Geneva as a Swiss tax-exempt foundation

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FIND and Operational Research in HIV-Associated Tuberculosis

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Find and operational research in hiv associated tuberculosis

FIND and Operational Research in HIV-Associated Tuberculosis

Rick O’Brien

Foundation for Innovative New Diagnostics, Geneva


Background and history

FIND was established in 2003 with a grant from the Bill and Melinda Gates Foundation

FIND is based in Geneva as a Swiss tax-exempt foundation

FIND is the only public / private partnership wholly dedicated to improved diagnostic technologies for infectious disease endemic in developing countries

FIND’s initial focus is on tuberculosis

Background and History


Find and operational research in hiv associated tuberculosis

FIND’s mission is to accelerate the development, evaluation, and appropriate use of high-quality yet affordable diagnostic tools for infectious diseases in developing countries.

FIND’s mission


Find and operational research in hiv associated tuberculosis

FIND SCOPE OF ACTIVITIES

Upstream

s

focus

Downstream

FIND

Market access

Discovery

and distribution

and research

-

Demonstration

Development

Evaluation

Large

-

scale

Facilitate,

Regulatory

-

projects

Proof of

Product

Efficacy

Effectiveness

co

-

fund,

quality

measuring

principle

in box

Data

Data

co

-

develop

lab & field

feasibility and

trials

impact on

disease control

programs


Find and operational research in hiv associated tuberculosis

Industry approach

Access

Liaise with funders, NGO’s, health ministries and agencies, e.g., GDF and GFATM

Demonstration

Evaluation

Regulatory quality lab and field trials

Large scale projects to measure feasibility and impact on disease control programs

Development

FIND

ACTIVITY

Research

Liaison with funders, pharmaceutical and biotechnology companies, research

institutes

and

academia

Facilitate, co- fund and co- develop

Proof of principle

Product in box

Efficacy data

Effectiveness data

FIND focus

Create network of public and private partnerships to create effective tests and demonstrate theireffectiveness


Find and operational research in hiv associated tuberculosis

easy & robust lab procedures

support for multiple health problems

universal platforms

dedicated POC devices

minimal skill requirements

segmentation - diagnostic question vs. health system level

RESOLUTION

faster than culture !

DETECTION

more sensitive than smear !


Find and operational research in hiv associated tuberculosis

Feasibility

Development

Evaluation

Demonstration

Access

Feasibility

Development

Evaluation

Feasibility

Development

Evaluation

Feasibility

Development

Evaluation

FIND product timeline

Development

Evaluation

Access

Feasibility

Demonstration

2005

2006

2007

2008

2009

Health center

Breath test

Adapted AFB

Ag detection

Serology

Automated AFB

Simple NAAT

Feasibility

Development

Evaluation

District lab

TK

Devel

Evaluation

Demonstration

Access

Fastplaque

Development

Evaluation

Demonstration

Robust NAAT

Fea

Development

Evaluation

MGIT

Demonstration

Access

Central lab

Current NAAT

Demonstration

Access


Find bd mgit demonstration projects

Formal agreement with BD Dec 04

FIND to undertake CF and DST demo projects

BD to supply MGIT equipment/reagents at “affordable” price to public sector in HBCs

FIND objectives

Demonstrate feasibility and impact of MGIT

Provide data for WHO recommendations

FIND-BD MGIT Demonstration Projects


Find bd mgit tb hiv case finding demonstration projects

FIND-CREATE MOU Dec 04

MGIT culture in support of studies in Zambia, South Africa, and Brazil

Under discussion

GAP/PATH/Tanzania NTLP

WHO/CDC/RIT-JICA/FHI/Cambodia MOH

AMPATH (Eldoret, Kenya)

FIND-BD MGIT TB/HIV Case-Finding Demonstration Projects


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