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HEART TRANSPLANTATION. Overall. NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR. AVERAGE CENTER VOLUME Heart Transplants: January 1, 1997 - June 30, 2003. DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUME Heart Transplants: January 1, 1997 - June 30, 2003.

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HEART TRANSPLANTATION

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HEART TRANSPLANTATION

Overall


NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR


AVERAGE CENTER VOLUMEHeart Transplants: January 1, 1997 - June 30,2003


DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUMEHeart Transplants: January 1, 1997 - June 30,2003


HEART TRANSPLANTS: Donor Age by Year of Transplant


AGE DISTRIBUTIONOF HEART RECIPIENTS(1/1982-6/2003)

% of Transplants


AGE DISTRIBUTION OF HEART TRANSPLANT RECIPIENTS BY ERA


HEART TRANSPLANTATION Kaplan-Meier Survival(1/1982-6/2002)


HEART TRANSPLANTATION

Adult Recipients


DIAGNOSIS IN ADULT HEART TRANSPLANTS


ADULT HEART TRANSPLANTATIONKaplan-Meier Survival by Era(Transplants: 1/1982-6/2002)

Survival (%)


ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group(Transplants: 1/1982-6/2002)


ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group(Transplants: 1/1996-6/2002)


ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Gender(Transplants: 1/1982-6/2002)


ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis(Transplants: 1/1982-6/2002)


ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis (Transplants: 1/1996-6/2002)


ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by PVR (Transplants: 1/1996-6/2002)


ADULT HEART RE-TRANSPLANTS1-Year Survival


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Age


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityDonor Age


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Height


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityCenter volume


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityIschemia time


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Bilirubin


ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient creatinine


ADULT HEART TRANSPLANTS(1/1995-6/2002)Factors Not Significant for 1 Year Mortality

Recipient Factors:

VAD, ABO identical/compatible, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, cardiac output, weight


ADULT HEART TRANSPLANTS(1/1995-6/2002)Factors Not Significant for 1 Year Mortality

Donor Factors:

Clinical infection, history of cancer, history of hypertension, history of diabetes, height, weight, cause of death

Transplant Factors:

Donor/recipient BMI ratio, donor/recipient weight ratio


ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality

(N=11,963)


ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality

(N=11,963)


ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality

(N=11,963)


Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient Age


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityDonor Age


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityDonor BMI


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient Height


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityCenter volume


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityIschemia time


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient creatinine


ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality

Recipient Factors:

VAD, in hospital, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, PA diastolic, PVR, history of malignancy, weight, gender, history of malignancy, bilirubin, PCW


ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality

Donor Factors:

Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes

Transplant Factors:

Donor/recipient BMI ratio, donor/recipient height ratio, CMV mismatch, ABO identical/compatible


ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year

(N=9,182)


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityConditional on Survival to 1 Year


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearRecipient Age


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearDonor Age


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearDonor BMI


ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearRecipient creatinine


ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year

Recipient Factors:

VAD, ventilator, in hospital, IV inotropes, balloon, ABO identical/compatible, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, PA diastolic, PCW, PVR, history of malignancy, height, weight, gender, diabetes, PRA, bilirubin


ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year

Donor Factors:

Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes

Transplant Factors:

Donor/recipient BMI ratio, donor/recipient height ratio, CMV mismatch, HLA mismatch, center volume, ischemia time

Post-transplant Factors:

Dialysis, prolonged graft dysfunction, permanent pacemaker


ADULT HEART TRANSPLANTS (1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years

(N=5,952)


ADULT HEART TRANSPLANTS (1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years


ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 YearsRecipient Age


ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor Age


ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor BMI


ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Center volume


ADULT HEART RECIPIENTS Functional Status(Follow-ups: January 1996 - June 2003)


ADULT HEART RECIPIENTSEmployment Status(Follow-ups: January 1996-June 2003)


ADULT HEART RECIPIENTSRehospitalization Post-transplant(Follow-ups: January 1996 - June 2003)


ADULT HEART RECIPIENTSInduction Immunosuppression (Follow-ups: January 2001 – June 2003)


ADULT HEART RECIPIENTSInduction Immunosuppression (Follow-ups: January 2001 - June 2003)


ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between January 2001 through June 2003

NOTE: Different patients are analyzed in Year 1 and Year 5


ADULT HEART RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-upFor follow-ups between January 2001 through June 2003

NOTE: Different patients are analyzed in Year 1 and Year 5


PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Type of Induction (Transplants: January 1, 2000 - June 30, 2002)


NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Type of Induction (Transplants: January 1, 2000 - June 30, 2002)


PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Maintenance Immunosuppression (Transplants: January 1, 2000 - June 30, 2002)


NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Maintenance Immunosuppression (Transplants: January 1, 2000 - June 30, 2002)


POST-HEART TRANSPLANT MORBIDITY FOR ADULTSCumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2003)


POST-HEART TRANSPLANT MORBIDITY FOR ADULTSCumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2003)


POST-HEART TRANSPLANT MORBIDITY FOR ADULTSCumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April 1994 - June 2003)


FREEDOM FROM CAV AND FREEDOM FROM SEVERE RENAL DYSFUNCTION*For Adult Heart Recipients (Follow-ups: January 1996-June 2003)


FREEDOM FROM CAV Stratified by DiagnosisFor Adult Heart Recipients (Follow-ups: January 1996-June 2003)


MALIGNANCY POST-HEART TRANSPLANTATION FOR ADULTSCumulative Prevalence in Survivors(Follow-ups: April 1994-June 2003)

”Other” includes: prostate (11, 33, 25), adenocarcinoma (7, 4, 2), lung (5, 3, 2), bladder (4, 5, 5), sarcoma (3, 3, 1), breast (2, 8, 6), cervical (2, 4, 1), colon (2, 2, 3), and renal (2, 7, 3). Numbers in parentheses are those reported within 1 year, 5 years and 7 years, respectively.


FREEDOM FROM MALIGNANCYFor Adult Heart Recipients (Follow-ups: April 1994 - June 2003)


ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years

(N=5,787)


Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years


ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years Recipient Age


ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years Donor Age


ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years Recipient BMI


ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years Center Volume


ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years Recipient Diastolic PA Pressure


ADULT HEART TRANSPLANTS (1995-6/1996)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year

(N=1,414)


Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

ADULT HEART TRANSPLANTS (1995-6/1996)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year


ADULT HEART TRANSPLANTS (1995-6/1996)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 YearRecipient Age


ADULT HEART TRANSPLANTS (1995-6/1997)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 YearDonor Age


ADULT HEART TRANSPLANT RECIPIENTS: Cause of Death(Deaths: January 1992 - June 2003)


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