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The Powell Lab is actively investigating the application of immune-based therapy for cancer. Building on interrogations in basic T cell biology in the lab, bench-to-bedside translational immunology is being developed, with a strong focus on T cell-based therapy for cancer.

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The Powell Lab is actively investigating the application of immune-based therapy for cancer. Building on interrogations in basic T cell biology in the lab, bench-to-bedside translational immunology is being developed, with a strong focus on T cell-based therapy for cancer.

Major areas of focus: Human Cancer Immunotherapy

  • Natural tumor-reactive T cells
  • Genetically modified lymphocytes (TCR/CAR)
  • Cancer vaccination & immunomodulation
  • Impact of costimulation on T cell function and memory formation
  • Innovative approaches to genetic engineering of T cells (Universal receptors and approaches)
  • Novel T cell isolation & expansion methods
  • Th9 cells in cancer

Unique resources:

  • Viable Primary Human Tumor Cell Bank
  • Human ovarian cancer cell lines, models
  • Unique lentiviral/retroviral constructs
  • Xenograft mouse studies

Collaborations:

  • Protein chemistry (looking for unique protein binding partners with high affinity)
  • Bispecific antibody production
  • Sensitive in vivo imaging for antibodies and cells
  • Costimulatory signal transduction cascades Rotations: available in Spring 2013.
  • TCR gene cloning
  • Mouse models of macrophage-involved Inflammatory Disease / Autoimmunity
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