1 / 9

Oral Health in Prader-Willi Syndrome

Oral Health in Prader-Willi Syndrome. Andrei Barasch, DMD, MDSc Chair, Dept. of Dental Medicine Winthrop University Hospital. Oral Changes in PWS. PWS is a multi-systemic genetic disorder (chromosome 15) Oral physiology and pathology not adequately studied

tala
Download Presentation

Oral Health in Prader-Willi Syndrome

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Oral Health in Prader-Willi Syndrome Andrei Barasch, DMD, MDSc Chair, Dept. of Dental Medicine Winthrop University Hospital

  2. Oral Changes in PWS • PWS is a multi-systemic genetic disorder (chromosome 15) • Oral physiology and pathology not adequately studied • The largest study included only 50 subjects aged 5 to 40 years (Saeves et al, Int J Ped Dent 2012) • Majority of publications are case reports

  3. Salivary Abnormalities in PWS • Decreased salivary flow has been the only consistently documented oral finding • Thick, sticky or frothy saliva is common • Amount produced equivalent to about 1/3 to 1/5 normal • Results in decreased cleansing, taste perception, remineralization, immune function

  4. Other reported oral findings • Mucosa: trauma due to picking; candidiasis • Dentition: hypodontia; enamel defects; rampant caries • Gums: periodontal disease

  5. Candidiasis

  6. Gingivitis

  7. Potential Solutions • Impeccable hygiene from the very start • Frequent dental appointments • Application of preventive measures (e.g. sealants, floride) • Avoid refined carbohydrates • Avoid lemon drops, even if sugarless • Avoid acidic foods and drinks • Rx: sialogogues and antimicrobial rinses

  8. The future • We need more study to better define problems and possible solutions • Potential identification of the genetic mechanism • Potential targeted therapy

More Related