1 / 12

Body Fluid Compartments and Fluid Balance

Body Fluid Compartments and Fluid Balance. Objectives. 1. Differentiate between the terms osmole, osmolarity, osmolality and tonicity. 2. List the typical value and normal range for plasma osmolality.

taipa
Download Presentation

Body Fluid Compartments and Fluid Balance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Body Fluid Compartments • and • Fluid Balance

  2. Objectives • 1. Differentiate between the terms osmole, osmolarity, osmolality and tonicity. • 2. List the typical value and normal range for plasma osmolality. • 3. Explain osmosis in terms of a differentially permeable membrane. • 4. Understand the concepts of osmosis and osmotic pressure. • 5. Define tonicity and be able to use the terms isotonic, hypertonic, and hypotonic. • 6. State the water content of the body, and its physiological variations with age, fat content and gender • 7. Understand the distribution of body water in the various body fluid compartments. • 8. Explain the principles of methods of measurement of body fluids. • 9. List the concentration of some important solutes in intracellular and extra cellular compartments. • 10. Understand the role of osmotic pressure in the distribution of body water into compartments.

  3. Some useful information -1 Mol OF Glucose solution? - 1 Mol NaCl solution? In the ECF, max contribution to Osmolalirty is by NaCl • One osmole is 1 gram molecular weight of undissociated solute. • Eg. 1 osmole of glucose = 180 grams of glucose , is equal to 1 osmole of glucose because glucose does not dissociate. • 1 gram molecular weight of NaCl (58.5 gm) is equal to 2 osmole because NaCl dissociates into Na+ and Cl- (both are osmotically active). • Osmolality A solution that has 1 osmole of solute dissolved in 1 Kilogram of water • Osmolarity A solution that has 1 osmole of solute dissolved in in 1 liter (1000 ml) of water . • Conventionally: because of low concentration, solute dissolved in mg/litre of water or Kg of H2O milliOsmole (mOsm) • Normal Osmolarity of plasma is about 300 mOsm/L

  4. Osmolarity/Osmolality • Is a measure of the total number of dissolved particles in a solution • Ionic composition of the ICF fluidisdifferent from that of ECF • But Osmolarity of ICF is equal to that of ECF.

  5. Concept of osmotic pressure Osmosis: Diffusion of H2O Across semi permeable membrane From high H2O concentration to low H2O concentration. In tissues - via lipid bilayer -Through water channels (acquaporins) H2O H2O Solute Movement of H2O Osmotic pressure is the pressure which is applied at the membrane to oppose osmosis Semi-permeable membrane Osmotic pressure is directly proportional To the osmolarity (solute concentration)

  6. Concept of hydrostatic pressure Pressure = 2 mmHg Pressure = 30 mmHg

  7. Principle of Osmosis Osmosis is the net movement of water molecules through a selectively permeable membrane During osmosis water molecules pass through a selectively permeable membrane in two ways (1) through the lipid bilayer and (2) through aquaporins (aqua = water) channels.

  8. The osmosis, diffusion, filtration and reabsoption provide for continual exchange of water and solutes (electrolytes) among different body compartments Yet, the volume of the fluid in different body compartments remains remarkably stable

  9. Body fluid compartment ECF also includes lymph, CSF, synovial fluid, aqueous & vitreous humor, endolymph & perilymph and fuild present in pleural, pericardial and peritoneal cavities

  10. Constitution of Extra and Intra cellular fluids

  11. Distribution of important ionic and organic constituents

More Related