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The Swedish Research Council Harriet Wallberg-Henriksson Secretary General, Medicine. VETENSKAPSRÅDET. THE SWEDISH RESEARCH COUNCIL. Sweden: Stem Cell Research. Outline. Legislation and Ethical Guidelines A Survey of Swedish Stem Cell Research 2002. Current Swedish legislation and

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The Swedish Research Council Harriet Wallberg-Henriksson Secretary General, Medicine

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The Swedish Research CouncilHarriet Wallberg-HenrikssonSecretary General, Medicine


VETENSKAPSRÅDET

THE SWEDISH RESEARCH COUNCIL

Sweden: Stem Cell Research

Outline

  • Legislation and Ethical Guidelines

  • A Survey of Swedish Stem Cell Research 2002


Current Swedish legislation and

EU convention

  • The law (1991:115) on proceedings for research and treatment with fertilized human eggs

    • contraceptives

    • development of the embryo

    • causes of malformations

    • involuntary childlessness

  • The biobank law (2002:297)

    • banking of biological material

    • collaboration and sharing

  • Council of Europe: Convention on human rights and biomedicine 1997

    • signed but not ratified by Sweden


  • Ethical Guidelines for Human Stem Cell Research

    Adopted December 3, 2001, by the Swedish Research Council

    • Stem cells from embryos from IVF

      • Surplus embryos from IVF is ethically acceptable to donated to research; informed consent from donors is necessary

      • Creation of embryos for research purposes only, is ethically unacceptable at this time


    Ethical Guidelines for Human Stem Cell Research

    Adopted December 3, 2001, by the Swedish Research Council

    • Somatic cell nuclear transfer (therapeutic cloning)

      • might be ethically acceptable, but can not be performed at this time due to the legal situation


    Legislation in Sweden:

    Regulating human embryonic stem cell research

    • informed consent needed by the donors of egg and sperm

    • the embryo must be destroyed within 14 days

    • an embryo can not be frozen for more than 5 years

    • a fertilized egg that has been used for research can not be inserted into a woman’s body

    • reproductive cloning not possible


    A Survey – March 2002Scientists involved in Stem cell research

    UniversityResearch Groups Researchers

    Umeå University1 11

    Uppsala University3 14

    Univ. of Agriculture1 2

    Karolinska Institutet10102

    Stockholm University4 20

    Linköping University2 6

    Göteborg University6 56

    Chalmers Univ. of Techn.2 12

    Lunds University4 65

    Total33288


    A Survey – March 2002Areas of stem cell research

    • Neurobiology

      • Majority of scientists

    • Haematopoietic research

      • Longest tradition

    • Embryonic stem cell research

      • 1/3 of the world´s human embryonic stem cell lines in Aug. 2001


    A Survey on Stem Cell Research – Conclusions

    • Relatively new area which was hard to define

    • Few, but successful groups

    • Publications were cited more than avarage

    • Economical support needed

    • Increased interactions with other fields would be benificial


    Human Embryonic Stem cell Research in Sweden

    • Two centers:

    • Karolinska Institutet,

    • Stockholm

      • Lars Ährlund-Richter

      • Outi Hovatta

    • Gothenburgs University,

    • Gothenburg

      • Henrik Semb

      • Peter Eriksson

      • Anders Lindahl

      • Lars Hamberger


    Karolinska Institutet

    • 2001

    • 6 genotypes – early cultures, frozen

    • thawing started – possible to recover?

    • 2002

    • 1 genotype - long term culture > 9 months

    • 3 genotypes - early cultures under expansion and analysis

    • 2 genotypes - early cultures frozen


    Gothenburg University

    Four human embryonic stem cell lines

    fully characterized

    Additional 8 lines under charaterization


    Funding programme of 75 milj. SEK 2003-2007

    • Juvenile Diabetes Research Foundation

      • 50 milj. SEK

    • Swedish Diabetes Association

      • 5 milj. SEK

    • Swedish Research Council

      • 20 milj. SEK

    • Two networks and 9 individual projects


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