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The Swedish Research Council Harriet Wallberg-Henriksson Secretary General, Medicine. VETENSKAPSRÅDET. THE SWEDISH RESEARCH COUNCIL. Sweden: Stem Cell Research. Outline. Legislation and Ethical Guidelines A Survey of Swedish Stem Cell Research 2002. Current Swedish legislation and

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The Swedish Research Council Harriet Wallberg-Henriksson Secretary General, Medicine

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The swedish research council harriet wallberg henriksson secretary general medicine

The Swedish Research CouncilHarriet Wallberg-HenrikssonSecretary General, Medicine


Sweden stem cell research

VETENSKAPSRÅDET

THE SWEDISH RESEARCH COUNCIL

Sweden: Stem Cell Research

Outline

  • Legislation and Ethical Guidelines

  • A Survey of Swedish Stem Cell Research 2002


The swedish research council harriet wallberg henriksson secretary general medicine

Current Swedish legislation and

EU convention

  • The law (1991:115) on proceedings for research and treatment with fertilized human eggs

    • contraceptives

    • development of the embryo

    • causes of malformations

    • involuntary childlessness

  • The biobank law (2002:297)

    • banking of biological material

    • collaboration and sharing

  • Council of Europe: Convention on human rights and biomedicine 1997

    • signed but not ratified by Sweden


  • Ethical guidelines for human stem cell research

    Ethical Guidelines for Human Stem Cell Research

    Adopted December 3, 2001, by the Swedish Research Council

    • Stem cells from embryos from IVF

      • Surplus embryos from IVF is ethically acceptable to donated to research; informed consent from donors is necessary

      • Creation of embryos for research purposes only, is ethically unacceptable at this time


    Ethical guidelines for human stem cell research1

    Ethical Guidelines for Human Stem Cell Research

    Adopted December 3, 2001, by the Swedish Research Council

    • Somatic cell nuclear transfer (therapeutic cloning)

      • might be ethically acceptable, but can not be performed at this time due to the legal situation


    The swedish research council harriet wallberg henriksson secretary general medicine

    Legislation in Sweden:

    Regulating human embryonic stem cell research

    • informed consent needed by the donors of egg and sperm

    • the embryo must be destroyed within 14 days

    • an embryo can not be frozen for more than 5 years

    • a fertilized egg that has been used for research can not be inserted into a woman’s body

    • reproductive cloning not possible


    A survey march 2002 scientists involved in stem cell research

    A Survey – March 2002Scientists involved in Stem cell research

    UniversityResearch Groups Researchers

    Umeå University1 11

    Uppsala University3 14

    Univ. of Agriculture1 2

    Karolinska Institutet10102

    Stockholm University4 20

    Linköping University2 6

    Göteborg University6 56

    Chalmers Univ. of Techn.2 12

    Lunds University4 65

    Total33288


    A survey march 2002 areas of stem cell research

    A Survey – March 2002Areas of stem cell research

    • Neurobiology

      • Majority of scientists

    • Haematopoietic research

      • Longest tradition

    • Embryonic stem cell research

      • 1/3 of the world´s human embryonic stem cell lines in Aug. 2001


    The swedish research council harriet wallberg henriksson secretary general medicine

    A Survey on Stem Cell Research – Conclusions

    • Relatively new area which was hard to define

    • Few, but successful groups

    • Publications were cited more than avarage

    • Economical support needed

    • Increased interactions with other fields would be benificial


    Human embryonic stem cell research in sweden

    Human Embryonic Stem cell Research in Sweden

    • Two centers:

    • Karolinska Institutet,

    • Stockholm

      • Lars Ährlund-Richter

      • Outi Hovatta

    • Gothenburgs University,

    • Gothenburg

      • Henrik Semb

      • Peter Eriksson

      • Anders Lindahl

      • Lars Hamberger


    The swedish research council harriet wallberg henriksson secretary general medicine

    Karolinska Institutet

    • 2001

    • 6 genotypes – early cultures, frozen

    • thawing started – possible to recover?

    • 2002

    • 1 genotype - long term culture > 9 months

    • 3 genotypes - early cultures under expansion and analysis

    • 2 genotypes - early cultures frozen


    The swedish research council harriet wallberg henriksson secretary general medicine

    Gothenburg University

    Four human embryonic stem cell lines

    fully characterized

    Additional 8 lines under charaterization


    Funding programme of 75 milj sek 2003 2007

    Funding programme of 75 milj. SEK 2003-2007

    • Juvenile Diabetes Research Foundation

      • 50 milj. SEK

    • Swedish Diabetes Association

      • 5 milj. SEK

    • Swedish Research Council

      • 20 milj. SEK

    • Two networks and 9 individual projects


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