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Cell death cascade complex

Cell death cascade complex. Signalization. Effector stage. Dismantling. Fas. FasL. Membrane. disruption. GzB. Cytoplasm. FADD. condens. Ag/MHC. NUR77. DAP-K. casp-8. blebbing. cleavage. TCR. Others ?. fragm. of. casp-7. gelsolin. Irradiation. Membrane. p53. BH3-only.

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Cell death cascade complex

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  1. Cell death cascade complex Signalization Effector stage Dismantling Fas FasL Membrane disruption GzB Cytoplasm FADD condens. Ag/MHC NUR77 DAP-K casp-8 blebbing cleavage TCR Others ? fragm. of casp-7 gelsolin Irradiation Membrane p53 BH3-only Genotoxic drug casp-3 alteration casp-6 Nucleus e.g. phosph.ser. drICE BMP-x ced-3 lamin Smad cleavage proteinase of PAK2 Nucleus (mouse and BMPR (chick) others) mammals Drosophila C.elegans nuclear reaper fragmentation casp-9 activation TR grim DRONC T3 chrom.condens. DIAP1 CAD of Hid sickle DNA fragm. DFF/ICAD Cyt c Glucosteroids Apaf-1 Dark ced-4 SR ATP AIF endoG smac/Diablo RAR Bid bcl-2s Drob-1 ced-9 Retinoic acid Mitochondria Omi/HtrA2 Schematic representation of molecular mechanisms of apoptosis. PG November 2008.

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