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The Human Phenotypic Disease Network

The Human Phenotypic Disease Network. Cesar A. Hidalgo Center for Complex Network Research, University of Notre Dame / Northeastern University. Collaborators. Nicholas Christakis Laurie Meneades Jason Block Dept. of Health Policy, Harvard Medical School. Christine Teutsch

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The Human Phenotypic Disease Network

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  1. The Human PhenotypicDisease Network Cesar A. Hidalgo Center for Complex Network Research, University of Notre Dame / Northeastern University

  2. Collaborators Nicholas Christakis Laurie Meneades Jason Block Dept. of Health Policy, Harvard Medical School Christine Teutsch Massachusetts General Hospital Harvard Medical School Laszlo Barabasi Nicholas Blumm Deok-Sun Lee J Park Center for Network Science, Northeastern University

  3. Some Diseases are known to be related

  4. There are no single causes for each disease Diabetes Obesity ENPP1 HFCS SLS Ectonuclide Pyrophosphate Phosphodiesterase 1 High Fructose Corn Syrup Sedentary Life Style

  5. Determining causes is labor and capital intensive

  6. Disease 1 Disease 2

  7. Disease 1 Disease 2 Affect Same Individuals Significantly more than Random

  8. Building a Net C12 N P1 P2

  9. Study Population ~ 13’039’018 patients 58.3% females, 90.1% white 7.5% black ~ 32’341’348 records (hospitalizations) Disease Fields Up to 10 diagnosis (from ~950 cat (3digit) / ~14000 (5digit) )

  10. Disease 2 Disease 1

  11. CHF

  12. CONCLUSIONS • We introduced the concept of a phenotypic disease network. • This network can be used to help explore life cycle strategies for drug companies and hospital design. • This network can be used to perform comparative studies. • Ultimately, the goal is to help determine disease ontology based on their comorbidity patterns

  13. http://www.nd.edu/~chidalgo Or Google: CA Hidalgo http://www.nd.edu/~networks Or Google: CCNR

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