On off flickering
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on-off flickering. voltage-dependent block by proton. node of Ranvier. 2-barrier model for proton block. well. outside. voltage-dependent block with TEA. K-depolarized squid giant axon. Time course of block by C9. squid giant axon. TTX-blocked iNa.

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On off flickering

on-off flickering


On off flickering

voltage-dependent block by proton

node of Ranvier


On off flickering

2-barrier model for proton block

well

outside


On off flickering

voltage-dependent block with TEA

K-depolarized squid giant axon


On off flickering

Time course of block by C9

squid giant axon

TTX-blocked iNa

internal C9 0.11 mM (nonyltriethylammonium)


On off flickering

Concentration-dependent block

internal TPeA (tetrapentylammonium)

+ 120 mV


On off flickering

Armstrong’s hypothesis for QA block

QA (quaternary ammonium)


On off flickering

use-dependent block with lidocaine

node of Ranvier, - 20 mV


On off flickering

internal NMS

(N-methylstrychnine)


On off flickering

QX-222 (quaternary lidocaine)

nicotinic AChR

frog sartorius muscle

-125 mV

-150mV

-120mV

-120mV

-150mV


On off flickering

multi-ion block in a long pore

selectivity filer


On off flickering

voltage-dependent multi-ion block

[K]o = 25 mM


On off flickering

flickering block by external Cs+

tunricate egg

Inward rectifier

200 mM [K]o

10 M [Cs]o


On off flickering

Long block dwell times with TTX and STX

batrachotoxin-Na channel, rat brain synaptosomes

symmetrical 200 mM NaCl, +50 mV


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