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on-off flickering. voltage-dependent block by proton. node of Ranvier. 2-barrier model for proton block. well. outside. voltage-dependent block with TEA. K-depolarized squid giant axon. Time course of block by C9. squid giant axon. TTX-blocked iNa.

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PowerPoint Slideshow about ' on-off flickering' - sydnee-gilliam


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voltage-dependent block with TEA

K-depolarized squid giant axon


Time course of block by C9

squid giant axon

TTX-blocked iNa

internal C9 0.11 mM (nonyltriethylammonium)


Concentration-dependent block

internal TPeA (tetrapentylammonium)

+ 120 mV


Armstrong’s hypothesis for QA block

QA (quaternary ammonium)


use-dependent block with lidocaine

node of Ranvier, - 20 mV


internal NMS

(N-methylstrychnine)


QX-222 (quaternary lidocaine)

nicotinic AChR

frog sartorius muscle

-125 mV

-150mV

-120mV

-120mV

-150mV




flickering block by external Cs+

tunricate egg

Inward rectifier

200 mM [K]o

10 M [Cs]o


Long block dwell times with TTX and STX

batrachotoxin-Na channel, rat brain synaptosomes

symmetrical 200 mM NaCl, +50 mV