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Scanpath variation in individuals with 22q11.2 deletion syndrome during the Benton Visual Retention Test . Marie-Christine Ottet, Bronwyn Glaser, Manolo Fuentes, Catherine Pasca, M él anie Chabloz, Martin Debban é , Stephan Eliez. How do we look at things ?. Why is this pertinent to VCFS ?.

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Slide1 l.jpg

Scanpath variation in individuals with 22q11.2 deletion syndrome during the Benton Visual Retention Test

Marie-Christine Ottet, Bronwyn Glaser, Manolo Fuentes, Catherine Pasca, Mélanie Chabloz, Martin Debbané, Stephan Eliez


How do we look at things l.jpg
How do we look at things ? syndrome during the Benton Visual Retention Test


Why is this pertinent to vcfs l.jpg
Why is this pertinent to VCFS ? syndrome during the Benton Visual Retention Test

Previous findings:

  • Deficits in attentional skills (Simon et al., 2002; Bish et al., 2005)

    • Efficient scanpath needs attention

  • Deficits of visuo-spatial memory (Bearden et al., 2001)

    • Alteration of parietal lobe (Simon et al., 2005)

    • Memory relies on visual exploration

  • Parents report an incomplete visual exploration


Population l.jpg
Population syndrome during the Benton Visual Retention Test

  • 78 participants

    • 41 VCFS and 38 Controls

    • Range of age : 8 to 26 years

  • 2 types of evaluation :

    • Cognitive: with an Eyetracker

    • Cerebral: with MRI scans


Benton visual retention test bvrt computer version l.jpg
Benton Visual Retention (Test BVRT) syndrome during the Benton Visual Retention Test Computer version

  • BVRT multiple choice

    • 10 cards with geometric figures


How to measure and analyze the scanpath l.jpg
How to measure and analyze the scanpath syndrome during the Benton Visual Retention Test

  • Eyetracker Tobii 1750

  • Measurements of the eyetracker

    • Total time and spread of exploration

    • Number, duration and coordinates of fixation points

  • Analyze regions of interest (AOI)

    • 3 groups of figures

      • Main simple figure

      • Main complex figure

      • Peripheral figure


Global results l.jpg
Global Results syndrome during the Benton Visual Retention Test

  • Less fixations

  • More spread

  • Same areas oberved

Controls

VCFS

Controls

VCFS


Results of aoi l.jpg
Results of AOI syndrome during the Benton Visual Retention Test

In red : lower number of fixations made by VCFS

10.78>8.67

8.45>6.83

10.24>8.63

2.68>1.44

Image 3

Image 1

Image 2

5.50>4.59

2.11>1.15

2.29>1.54

Image 4

Image 5

Image 6

3.58>2.56

2.34>1,51

1.45>0.98

1.39>0.83

1.76>1.12

5.87>4.22

Image 7

  • Image 8

Image 9

4.82>3.71

1.42>0.59

Image 10


Results analysis of aoi l.jpg
Results: Analysis of AOI syndrome during the Benton Visual Retention Test

  • Less fixations on :

    • 7 of 8 peripheral figures

    • 5 of 7 main simple figures

  • 2 influences:

  • Spatial deficits

    Lateral « negletion » of the image

    • Less fixations on peripheral figures

    • Alterations of the parietal lobe

  • Attentional deficits

    Deficit in attentional disengagement

    • Less fixations on main figures simples

    • Alterations of the frontal lobe

  • Image 1

    Image 2

    Image 3

    Image 5

    Image 6

    Image 4

    Image 7

    • Image 8

    Image 9

    Image 10


    Anatomical cerebral measurments l.jpg
    Anatomical cerebral measurments syndrome during the Benton Visual Retention Test

    • Method : FreeSurfer (http://surfer.nmr.mgh.harvard.edu/)

    Measure of the volume of gray matter of the cortex

    • parcels of frontal lobe

    • parcels of parietal lobe

    Automatic subdivision of the cortex: Desikan, R.S., (2006)


    Analysis of parcel volumes related to the scanpath l.jpg
    Analysis of parcel volumes related to the scanpath syndrome during the Benton Visual Retention Test

    Left hemisphere

    • Correlations controled for age and gender between :

      • Gray matter volume

      • AOIs

    • Caudal middle frontal

    • Precentral

    • Postcentral

    • Superior frontal

    • Anterior cingulate

    • Parahippocampal

    Right hemisphere

    • Caudal middle frontal


    In summary l.jpg
    In summary syndrome during the Benton Visual Retention Test

    • Same areas observed between groups but less precise scanpath in VCFS (number, duration and spread)

    • Deficits attentional and spatial on global scanpath

    • Possible alteration of the motor planification


    How do our results guide interventions l.jpg
    How do our results guide interventions ? syndrome during the Benton Visual Retention Test

    • Importance in treatment of attentional deficit:

      • Cognitive remediation

      • Medical treatments

    • Strategies

      • Always start with the sides of images

      • Salient stimulus on important items (e.g. key word in red for homework)


    Thank you l.jpg
    Thank you… syndrome during the Benton Visual Retention Test

    … for your attention


    Acknowledgment l.jpg
    Acknowledgment syndrome during the Benton Visual Retention Test

    Thanks to the associations

    Generation22

    Connect22

    Relais22

    Financial Support

    SNF

    CIBM

    Eagle

    FHMS

    NARSAD

    Von Meissner

    Thanks to collegues

    Stephan Eliez

    Martin Debbané

    Bronwyn Glaser AnnaLaura Lagioia Marie Schaer

    Maude Schneider

    Catherine Pasca

    Mélanie Chabloz

    Bertrand Auckenthaler

    Michal Epstein

    Catherine Audrin

    Manolo Fuentes

    Ryan Murray

    Thanks to all the families


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