Retroviral links to cancer
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Retroviral Links to Cancer. Gilbert W ColeUniversity of North Carolina At Charlotte Sandra Gesing Ph.D. University of Edinburgh. Regulatory Networks & miRNA. Gene Regulator Networks control the functions of the cell Molecular Signals are used for intracellular communication

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Retroviral Links to Cancer

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Retroviral links to cancer

Retroviral Links to Cancer

Gilbert W ColeUniversity of North Carolina At Charlotte

Sandra GesingPh.D.University of Edinburgh


Regulatory networks mirna

Regulatory Networks & miRNA

  • Gene Regulator Networks control the functions of the cell

  • Molecular Signals are used for intracellular communication

  • Micro RNA (miRNA) is used as a molecular signal typically to inhibit transcription or translation of other molecular signals or genes.

  • Alien miRNA introduced into the cell could disrupt the regulatory networks within the cell resulting in a cancerous cell.

  • miRNA is typically between 18 – 25 base pairs in length


Retroviruses

Retroviruses

  • Retroviruses enter and infect cells as RNA the convert themselves into double stranded DNA and insert themselves into the host genome.

  • Once the retrovirus has inserted itself into the host genome, the host will make new copies of the virus that can infect other cells.


Retroviral mirna

Retroviral & miRNA

  • Retroviruses can pick up regions of their host during the replication process.

  • These regions may contain gene segments that can act as miRNA

  • 4 Essential genes of a retrovirus (GAG, PPT, POL and ENV)

  • Unspecific gene regions (U3 and U5)

  • Repetitive sequence regions (R)

  • The U3 and U5 regions are locations

    where miRNAs could be located


Gpu search tool

GPU Search tool

  • Development of a GPU based search tool.

  • The search tool will be written in both CUDA and OpenCL to determine the most efficient GPU method for the search tool.

  • The algorithm will use the 4 genes, gag, ppt, pol and env to locate the retroviruses.

  • Once these regions are found we will search the regions beteween the 4 genes against the miRNA database for matches with high confidence.

  • The tool will search for both the miRNA and its reverse compliment to also find potential interfering RNAs (RNAi). When a match is found the tool will report the match location and miRNA sequence.

  • It is hoped that this information will help in the development of cancer treatments.


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