Mechanisms that
Download
1 / 12

Mechanisms that Produce a Stroke - PowerPoint PPT Presentation


  • 99 Views
  • Updated On :

Mechanisms that Produce a Stroke. Blockage of an artery (80% of strokes) -- causes ischemia (inadequate blood flow) This deprives the brain of oxygen and glucose, and slows waste removal -- affected brain tissue functions abnormally or stops

Related searches for Mechanisms that Produce a Stroke

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Mechanisms that Produce a Stroke' - stu


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Slide1 l.jpg

Mechanisms that

Produce a Stroke

  • Blockage of an artery (80% of strokes)

    • --causes ischemia (inadequate blood flow) This

    • deprives the brain of oxygen and glucose, and

    • slows waste removal

    • --affected brain tissue functions abnormally or stops

    • functioning, and will die if ischemia persists

  • Rupture of an artery (20% of strokes)

  • --causes hemorrhage within or around the brain. This

  • distorts, compresses, and tears surrounding tissue

ventricle

Lumen


Slide2 l.jpg

Stroke Risk Factors

Relationship to pathology

Directly or indirectly promote conditions that ‘encourage’ blockage or rupture of arteries supplying the brain:

ventricle

  • Development of atherosclerotic plaque

  • Thrombus formation in heart or cerebral arteries

  • Physical stress and direct damage to walls of

  • large and small arteries

Lumen


Slide3 l.jpg

Stroke Risk Factors

Behaviors / Lifestyles

‘Who We Are’

Medical Conditions

(treatable/controllable)

Age

Gender

Race/Ethnicity

Family History

Prior Stroke/TIA

Cigarette Smoking

Physical Inactivity

Excess Alcohol Use

Obesity

Hypertension

Heart Disease

Myocardial Infarction

Atrial Fibrillation

Diabetes Mellitus

Hyperlipidemia

Carotid Stenosis

ventricle

Lumen


Slide4 l.jpg

Stroke Risk Factors

Behaviors or Lifestyles

  • Cigarette Smoking

    • Increases risk about 1.5X

    • The heavier the smoking, the greater the risk

    • 5 years after quitting, risk matches that for nonsmokers

  • Physical Inactivity

    • Sedentary lifestyle is independent risk factor

    • (30 min. moderate-to-vigorous daily exercise recommended)

  • Excessive Alcohol Consumption

    • ≥ 5 drinks/day and binge drinking

  • Obesity

    • Body mass index ≥ 30 doubles risk

ventricle

Lumen


Slide5 l.jpg

Stroke Risk Factors

Medical conditions: treatable or controllable

  • Hypertension

    • Blood pressure ≥ 140/90 mm Hg for extended periods

  • Heart Disease

    • Myocardial Infarction

    • Atrial Fibrillation

  • Diabetes Mellitus

    • Fasting plasma glucose ≥ 126 mg/dL

  • Hyperlipidemia

    • Total cholesterol ≥ 240 mg/dL accelerates atherosclerosis

  • Carotid Artery Stenosis

    • ≥ 70% narrowing of the carotid artery in the neck

  • Hypertension is the most significant treatable risk factor!

increase risk of thrombus formation

in heart, and thus embolic strokes

ventricle


Slide6 l.jpg

Stroke Risk Factors

Unmodifiable conditions: ‘Who we are’

  • Age

    • Risk of stroke doubles every 10 years after age 55

  • Gender

    • Women’s first strokes occur when they are older

  • Race/Ethnicity

    • African-Americans 60% more likely to have a stroke,

    • and twice as likely to die compared to other groups

  • Family History

    • First-degree relative with stroke

    • Inherited defects influencing blood clotting

  • Previous Stroke or TIA

    • 1:6 ischemic stroke survivors has another stroke in 2 yrs

    • Having a TIA increases the chances of stroke 10 times

ventricle

Lumen


Slide7 l.jpg

plaque

Basilar Artery

atherosclerotic plaque narrows lumen ( )


Slide8 l.jpg

Aorta - Atherosclerosis

Numerous ulcerated plaques


Slide9 l.jpg

Carotid Bifurcation

atherosclerotic plaque and thrombus

Thrombus on

plaque surface

plaque

Thrombus on

plaque surface


Slide10 l.jpg

Embolus Plugging Artery

Piece of thrombus that traveled from heart

Arterial wall

ventricle

Lumen

Plugged lumen


Slide11 l.jpg

Intracerebral Hemorrhage

ventricle

Lumen

Clotted

blood


Slide12 l.jpg

Intracerebral Hemorrhage

CT Scan - 3 Hours after onset of symptoms

ventricles


ad