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Education and Career Development Workshop

My Science Career -- How do I Keep Moving Forward?. Christopher C. Broder Uniformed Services University, Bethesda, MD. Education and Career Development Workshop. ASV – 2011 Minneapolis. Ph.D. Thesis (89’), University of Florida, Gainesville.

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Education and Career Development Workshop

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  1. My Science Career -- How do I Keep Moving Forward? Christopher C. Broder Uniformed Services University, Bethesda, MD Education and Career Development Workshop ASV – 2011 Minneapolis

  2. Ph.D. Thesis (89’), University of Florida, Gainesville Streptococcus pyogenes surface proteins as receptors for human plasmin. HIV Entry (1989) Vincent A. Fischetti Grewe & Geldeblom

  3. CXCR4 CCR5 HIV Tropism Dimiter (Mitko) S. Dimitrov, Sc.D.,Ph.D. NCI-Frederick, Frederick, MD Broder, C.C., D.S. Dimitrov, R. Blumenthal, and E.A. Berger. The Block to HIV-1 Envelope Glycoprotein-Mediated Membrane Fusion in Animal Cells Expressing Human CD4 can be Overcome by a Human Cell Component(s). Virology. 193:483-491, 1993. HIV Entry Think of new approaches and seek new collaborations

  4. “A wise man will make more opportunities than he finds” Sir Francis Bacon English author, courtier, & philosopher (1561 - 1626) ...

  5. Seek out new collaborations------ it works! Oligomeric HIV-1 Envelope (gp140)--- --with Pat Earl and Bob Doms (LVD, NIAID) Broder, C.C., P.L. Earl, et al., Proc. Natl. Acad. Sci. USA. 91:11699-11703, 1994. Earl, P.L., C.C. Broder, et al., J. Virol. 68: 3015-3026, 1994.

  6. HIV tropism and entry…… Start off with the most active and successful part of your research activities- Broadly Effective Neutralization and CTL against HIV-1 P01 - NIAID HIV-1 Fusion Cofactors R01 - NIAID High Potency HIV-1 Broadly Cross-Reactive Neutralization U01 – NIAID, 08’ HIV-1 Fusion Cofactors R29 – NIAID, 96’ Analysis of Oligomeric HIV-1 Envelope Glycoproteins R21 - NIAID HIV-1 Envelope-CD4-Coreceptor Complexes as Vaccines R21 - NIAID Transition from postdoctoral position to academia--- (Assistant professor -1996, Uniformed Services University) This worked: (Associate Professor - 2000, Uniformed Services University)

  7. Now what? How to make that next transition to Professor? How about trying something “completely-different” as part of your research activities-

  8. Reinvent some of your research endeavors…. Seek out new collaborations------ it works!

  9. Lin-Fa Wang, Ph.D. CSIRO, Australian Animal Health Laboratory, Geelong, Australia Hendra virus 1999

  10. “Small opportunities are often the beginning of great enterprises” Demosthenes (384 BC - 322 BC)

  11. Nipah/Hendra Subunit Vaccines R21 - NIAID Nipah/Hendra Virus Entry and Assembly R01 - NIAID Nipah/Hendra Peptide Therapeutics U01 – NIAID, 2003 Biodefense and Emerging Infectious Diseases Research (bat lyssavirus) U54-(RCE) - NIAID Biodefense and Emerging Infectious Diseases Research (Nipah/Hendra) U54-(RCE) - NIAID Vaccines/Therapeutics for Nipah/Hendra U01 - NIAID Nipah/Hendra Nonhuman Primate Models Therapeutics Development U01 – NIAID Human monoclonal antibody protection against Hendra virus in NHPs, ASV-2011, 40-1 Katharine Bossart, Ph.D. New grounds…. This worked as well: (Professor - 2005, Uniformed Services University)

  12. Australian Bat Lyssavirus (ABLV) Keep moving forward Seek out new collaborations------ it still works! Structural Biology Program Memorial Sloan-Kettering Cancer Center, New York Dimitar B. Nikolov and Kai Xu Thomas Geisbert Linfa Wang Ina Smith Nonhuman Primate Models for Henipaviruses

  13. A couple of take home messages---- What has worked for me………. #1 -- Seek out new collaborations-- it usually works!

  14. Doing so can help you stay energized ---- but also….. A couple of take home messages---- What has worked for me………. #2 --About every 5 years --- Reinvent at least a third of your research program…

  15. Gives you new or different research funding opportunities to pursue. Attracts new students and young scientists with different interests and talents --- adding depth to your team. Periodically reinvent your program……

  16. Often, to achieve success in doing this, those new research directions will be related to your current productive programs

  17. Studies on henipavirus - entry Viral membrane glycoproteins Hendra sG Diagnostics Vaccines Sero-surveillance Immunotherapy Human mAbs m102.4 Hendra sG An excellent example…..

  18. A couple of take home messages---- What has worked for me………. #3 -- Always look down the road about 2 to 3 years…. Keep an eye out for new opportunities and always be aware of the limits of your resources.

  19. Be aware of the limits of your resources----to keep your lab and staff supported- especially those students that have committed themselves to your laboratory. Stephanie Petzing USU/EID Bat derived cells and emerging viruses ASV-2011, W39-3 Dawn Weir USU/EID Australian bat lyssavirus – tropism ASV-2011, P1-14 m102.4 Andrew Hickey, MPH, Ph.D. sG-vaccination in NHPs ASV-2011, W40-2 Deborah Steffen – USU/EID Next-Generation human mabs against henipaviruses ASV-2011, W42-8

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