Hypothalamus and its hormones, hormones of the pituitary gland. Romana Šlamberová, M.D. Ph.D. Department of Normal, Pathological and Clinical Physiology. The h ypothalamus. Hormonal (anterior portion) or nervous (posterior portion) control of the pituitary gland
Romana Šlamberová, M.D. Ph.D.
Department of Normal, Pathological and Clinical Physiology
Hormonal (anterior portion) or nervous (posterior portion) control of the pituitary gland
Hormones secreted and transported to anterior pituitary through hypothalamic-hypophysial vessels to pituitary sinuses
Major hypothalamic releasing hormones:
Major hypothalamic inhibitory hormones:
Other hormones of adenohypohysis
ADH (vasopressin): Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-GlyNH2
– stretch (volumoreceptors) in right atrium of the heart
- baroreceptors in carotid, aortic and pulmonary regions
hGH has DIABETOGENIC EFFECT
= growth hormone-induced “insulin resistance” attenuates insulin’s actions, such as:
This leads to increase of glucose concentration in the blood and compensatory increase of insulin.
Excess in hGH may cause metabolic disturbance similar to those found in patients with DM II.
Cartilages and bones are the main tissues of hGH action
Similar effect as insulin = IGF (insulin-like growth factors)
Function: support the action of hGH (unclear is if the hGH may act without somatomedines or not)
Somatomedin C = IGF I
hGH is secreted in pulsation – increasing and decreasing