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第 十 六 章 PowerPoint PPT Presentation


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第 十 六 章. 血液的生物化学. Hemal Biochemistry. 具有黏滞性的循环于心血管系统中的 流动组织 。与淋巴液、组织间液一起组成细胞外液,是体液的重要部分。. 2 、 总量 占体重的 8% 一次失血 <10% 总量 一次失血 >20% 总量 一次失血 >30% 总量. 70~80ml/Kg 对身体影响不大 严重影响身体健康 危及生命. 3 、功能. 沟通内外环境及机体各部分 维持机体内环境的恒定 物质运输 免疫 凝血、抗凝血 血液中某些代谢浓度的变化,反映体内代谢或功能状况. 概论 血液的组成及其化学成分.

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第 十 六 章

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Hemal Biochemistry


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2 8%

<10%

>20%

>30%

70~80ml/Kg


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3


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1.

2.

blood)plasma) serum)


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=+()

=-(,,)

=--


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81%--86%

93%--95%

O2CO2N2


1 2 npn

1 2NPN


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3 ureauric acid creatinecreatinine bilirubin

4

1

2


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*

*


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1. 60-80g/L (Total protein,TP) 2. 1 A.

albumin (globulin) (fibrinogen)


B 1 2 35 55g l 20 30g l a g 1 5 2 5 1 2

B.1235-55g/L20-30g/LA/G 1.5-2.5/12

1

+

2

Alb


A b c d e

a. b. c. d. e.


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.

pH

1.

2. pH:7.357.45 -(Na-Pr/HPr)

(pI:46)


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1.

2.


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1. VitA

2.,

3.


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4.

(1) haptoglobin,HP

(2) : Fe3+

(3)( Fe2+ Fe3+ + e


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immunoglobulin,Ig complement()


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Metabolism of Blood Cells


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+-

*-


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1. 2, 3-(2, 3-BPG)

2. , NADPH+H+


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1, 3-BPG

3-

2, 3-BPG

2, 3-BPG

3-

2,3-BPG


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3.

ATP

  • (Na+-K+-ATPase)

  • (Ca2+-ATPase)

  • ATPNAD+

  • ATP


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2, 3-BPG

  • 2, 3-BPG(Hb)


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6-

NADP+

2GSH

H2O2

6

6-

2H2O

NADP++H+

GSSG

NADHNADPH


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(heme)

*

*

*


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1.

CoAFe2+


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HSCoA + CO2

ALA

1

---(- aminolevulinic acid ,ALA)ALA(ALA synthase)

+


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ALA

2H2O

    • ALA


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4x


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CoAFe2+


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  • ALA


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  • ALA

    • ()

  • (erythropoietin, EPO)


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/

:


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2.


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1


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+

eIF-2

P

ATP

ADP

+

eIF-2

P

ATP

ADP

2

cAMP +

2C+cAMP-2R

R2C2

(PKA)

eIF-2

eIF-2


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NADPHO2H2O2OH


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:(Hb) :


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: : , : */VC, * *: :

*

*


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18-3

3

2

1


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blood coagulation

+

+

-

-


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()1. 142. ----3. ,----------4. ----HMWK ----


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18-1


1 vitk 1 2 n glu carboxyglutamate gla

() 1. VitK1 : 2 :NGlu-carboxyglutamate,Gla


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Gla

-Glu

---VitK() 18-2

18-2


3 gla 2 ca 2 pt 4 vitk vitk

----3:Gla2-- Ca2+ ---/PT 4VitKVitK---


2 ser 1 pk 2 aa ser 3 arg

2.Ser1PK2:AASer3Arg


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3.(1) Ca++HMWK(2) A. ( tissue factor,TF12


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B. /1//

2v

3vWF

PT


C hmwk 1 a pk 2 d ca ca

C. HMWK1aPK2D. Ca--- Ca---


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4.------


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intrinsic coagulation pathwayextrinsic coagulation pathway common pathway


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18-4


1 contact activation

1 contact activation

H


2 1 2 3 b

2* 1. 2.3.* B


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3 : ------- A : a--Ca2+ -- () -- Ca2+ --a() + Ca2+ a- Ca2+ --------


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1TF--- N-------C----2-- Ca2+ --a Xa


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--------a1a. PT b. a : 2-------I


2 1 a b 2 2 3 i 4

2. (1)(A B)2(2)(3)() I (4)()


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18-5


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,

Ia/Ca++

()


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I

1

2

18-6


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PT - Ca2+ -


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18-4


1 2 3 4 5

1. 2. 3.4. 5.


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antithrombin ,AT- 2 aaaaa PK 11AT-Arg Ser


Heparin 18 7 at

heparin18-7AT-


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+

AT-Lys

AT-


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CPCSPSVitKGla PC PSPCPC


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4TFPIPT 1 -- Ca2+ -- a 2a


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------------------ AT-

---- Ca2+

EDTA Na2


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  • .:

  • -----

  • :

  • 1.:

  • 2.:


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18-8


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1. (1) Pka (2) t-PA (3) t-PA()u-PA()


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Ser

1

2

3


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2.

fibrin degradation products,FDP

1

2 FDP-----

XY

DE

18-9


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  • 1 plasminogen activation inhibitor,PAIt-PAu-PA

  • **

  • 2

  • 2 (2-antiplasmin, 2-AP) *

  • *2-AP

  • I


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1.Vit k

2.

3.

4.DIC()

/


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ATP


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