Phase I Drug Development: Early Indications of Antitumor Activity for Sarcoma Patients and Opportunities for Progress. Anthony Tolcher Director of Clinical Research Institute for Drug Development CTRC, San Antonio TX. Phase-1-ologist. Pronounced: faez ·won·ole·geest Definition:
Director of Clinical Research
Institute for Drug Development
CTRC, San Antonio TX
1small curious creature that inhabits Texas, Ohio, California, and occasionally Arizona.
2Exhibits animated activity when exposed to novel chemical structures or mechanisms of action
3Becomes ecstatic if one patient in 40 has response
May 18 2004
Sep 15 2004
34 yr old female with GIST Refractory to Gleevec, ET743 and others
Regulatory Success from phase I activity
Adapted from Johnstone et al. Cell. 2002.
Kinesin 1 inhibitors
Aurora Kinase Inhibitors
Polo kinase inhibitors
C-mycCurrent Phase I Targets