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Automated Mini-Store

Automated Mini-Store. System for Low-Temperature Samples Storage. Lab Automation solutions. by PAA/Biosero. Focused offerings for high-throughput screening applications. Automated Samples Storage Systems. Range of capacities and functionalities.

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Automated Mini-Store

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  1. Automated Mini-Store System for Low-Temperature SamplesStorage

  2. Lab Automation solutions by PAA/Biosero Focused offerings for high-throughput screening applications

  3. Automated Samples Storage Systems • Range of capacities and functionalities • Ultra-low temperature robotic sample storage • Automation integration – Front/back-end

  4. Targeted for manual and automated work-processes Dry, inert, oxygen-free, ionized, temperature-controlled atmospheres possible Dry, nitrogen atmosphere for automated liquid-handling workcell Dry, nitrogen atmosphere for samples weighing Controlled-Environment Chambers

  5. Automated Mini-Store (AMS) For small-medium libraries

  6. General features • Standalone, self-contained, mobile • Configurable for range of tubes and vials • Cherry-picking capability • Medium-capacity; expandable • Modular design

  7. AMS Features and Specifications 1/2 • System Size: 8’ wide, 5’ deep, 6.5’ tall • Capacity: 300,000 micro-tubes (0.7ml) • Throughput: 4000 picks/day; higher possible • Cherry-picking: Yes, for 96- and 384-well • Operating environment: • +4ºC to -20 º C (settable) • -80 º C option available • Environment Backup: Liquid Nitrogen

  8. AMS Features and Specifications 2/2 • Input/Output Station: Positions for 6 racks • Output Stacker: 24 racks capacity • Compression/Consolidation: • On-demand or auto • Database: Any SQL database • Samples ID: 2D matrix and 1D barcode

  9. 96-well Tubes, Standard-height (1.4 ml) 275,000 tubes (max 300,000) 96-well Tubes, Half-height (0.7 ml) 175,000 tubes (max 190,000) Picoplates (or Microtiter plates) 1.9 Million picotubes2.6 Million in stacked configuration Other Container Types Vials, custom racks and tubes are possible Container Types and Capacity

  10. Multi-Container Types in Single AMS AMS can easily be configured to simultaneously handle multiple container types in a single system. This is achieved by using gripper-changers at the Picking Robot for handling each container-type (similar to our larger ASRS) Note, however, that this affects the overall throughput of the system (and some loss of flexibility)

  11. Modules View – Main Discrete Modules Picking Module Storage Module #1 Storage Module #2 Input/Output Module

  12. Single Pan Modules View – Storage Stack Storage Stack

  13. Modules View – Picking Module Extractor Extractor transfers product from storage module to picking module Picker Picker (robot) cherry-picks samples from source-racks to destination racks

  14. Modules View – Pan in Extractor

  15. Picking Module – Picking Station Cherry-Picker Can pick tubes and vials of various sizes I/O Buffer I/O Buffer can hold 6 racks

  16. Pan Extracted for Picking Extractor Picker Source Rack I/O Module

  17. Modules View – I/O Module System display I/O Stacker Rack Scanner

  18. Dry Inert enclosure for plate thawing • Inert / dry plate exit hotel • Dry Nitrogen atmosphere • Room Temperature thawing • Recirculation with inline warming & desiccating module. • Intelligent control with O2 and humidity sensors to monitor environment • Minimal N2 consumption

  19. Sample Retrieval from the Inert hotel The available capacity of the Hotel allows for batch loading of tube racks into the AMS. Tube racks can be efficiently handled in batches using ‘Cassettes’, with a capacity of 10 tube racks each. The antechamber allows product transaction without compromising the internal atmosphere

  20. Cycle Times The adjacent graph shows the dependency of cycle-time to picking efficiency. If the inventory is fragmented, or if pick request is characterized by dispersed samples, the throughput will be lower. For pan extractions in the range of 1 to 20, the steep slope of the graph underlines the advantages of condensed/optimized storage. Important note: these numbers are for serial service of tube racks (not picked in batches, which AMS can do, up to 6 tube racks at once). With batch picking, throughput will be higher.

  21. Feature RANDEX AMS Throughput Cherry-pick of 4 96-well tube racks per hour, on average (see conditions) Temperature Yes, settable between +4C and –20C Redundancy/backup In case of power failure or refrigeration system failure, liquid nitrogen backup (option) Humidity Control Built-in dehumidification control Container Types, Capacities 300,000 0.65ml Micronic micro-tubes in their racks: (height: 32 mm); 267,264 0.75ml Matrix micro-tubes in their racks: (height: 40 mm) Cherry-Picking Micro-tubes are cherry-pickable. Cherry-picking is done inside the controlled environment System Size and weight AMS Standard Size: 8’ wide, 5’ deep, and 6.5’ tall. Weight: 2,500 lbs AMS with Integrated Hotel: Barcode scanning 1D barcode scanning of racks. 2D cluster scanner for identification of microtubes Input/Output AMS Standard via front stacker (24 tube racks), or serially. AMS with Integrated Hotel: automatic transfer of tube racks to and from Liconic LPX-200 Hotel. Hotel capacity is 100 tube racks Compression/ Consolidation Micro-tube compression. Can also compress by custom-defined field (project/department) Inventory Data Will reside in your enterprise database or in our MSDE (SQL) database Service Support 24 hour turnaround in support and service AMS System Features

  22. Process – Storing Plates/Racks Process for Storing Racks with 2D ID underside

  23. Process – Retrieving Samples

  24. Software/Data Integration to LIMS We can integrate our systems seamlessly into your LIMS

  25. Data Model

  26. Inert Sample Processing Human and Robotic Solutions

  27. A Precipitous Problem WebData from Labcyte.com water absorption vs. time (hrs) WebData from Tekcel.com water absorption vs. time (hrs) WebData from Waybright et al., NCI sample precipitation • Samples absorb 10% water in 4 hours under ambient conditions • This will prevent freezing @ 20 C and compound precipitation • Sample precipitation occurs under such sub-optimal conditions • HTS and hit-to-lead follow-up are compromised • Consensus is that dry sample processing is a component of valid compound management for HTS

  28. Precipitation = More False Negatives How Much Does a False Negative Cost? Opportunity and Operations Loss

  29. Solutions to a Common Problem Cost:Benefit • Good: Dry boxes for thawing plates • Better: Semi-automated processing in inert enclosure • State of the Art: ASRS and Integrated Workcell

  30. Summary: Dry Box Solution

  31. Summary: Dry Box Solution • Obligatory for thawing/conditioning plates • Rapid dry equilibration of chamber • Gentle, ‘Power Thaw’ option • <1% Relative Humidity achievable • Requires only power outlet • Movable, space efficient and affordable • Vastly superior to passive desiccant • Custom configurations and options available

  32. Sealer Input Airlock Output airlock Inert/dry atmosphere controls Glove ports Height adjustable Mobile (casters) Semi-Automated (‘Hubotic’) Solutions Pipettor Stackers • 1/10 cost of alternative solutions by redeploying existing equipment

  33. Summary:‘Hubotic’ Solution • Powerful workflow model. Simple and very cost-effective • Pressurized with dry argon gas, data monitored and logged • Inert processing from solubilization to seal • Movable, ergonomically adjustable • Continuous Batch Processing without breaking the conditioned environment

  34. Fully Integrated Robotic Solution • Turnkey System to your specifications • Compact, movable, cost-effective • From an established leader in Materials Management

  35. Buffer Stack for Empty Plates Buffer Stack for Thawing Racks Shuttle between AMS and PPW Automated Mini-Store Plates Processing Workstation (AMS) (PPW) Operational Schematic Buffer Stack for RandomAccess (of 384-well Plates) Transfer Robot Liquid Handling System Air-Lock PlateLoc Plate Sealer

  36. Compound Management Solutions • Samples must be processed in dry environment • Simple solution is the DB500 for manual processing • prevents water absorption during plate thawing • Continuous Batch Processing with Enclosure • emulates robotic solution (‘Hubotic’) at low cost • Fully Integrated AMS: Best of both worlds • Turnkey ASRS integrated turnkey sample processing • Attractively priced, compact footprint • Service and support • Tried and tested technology

  37. Appendix - (384-well) Picoplate Bite and Place • Field-proven, patented design • Source plate is single molded part – Low cost • Cherry pick capability – no freeze-thaw cycle Source Plate Destination plate

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