Ety 494
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ΜΑθημα ETY-494 «Ειςαγωγη ςτην ΒιοϊατρικΗ ΜηχανικΗ» PowerPoint PPT Presentation


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ΜΑθημα ETY-494 «Ειςαγωγη ςτην ΒιοϊατρικΗ ΜηχανικΗ». Τμήμα Επιστήμης και Τεχνολογίας Υλικών , Σχολή Θετικών Επιστημών, Πανεπιστήμιο Κρήτης Δρ. Γ εώργιος Βλαστός (E-mail: [email protected]) Ιστοσελίδα Μαθήματος: http://www.materials.uoc.gr/courses/ETY494.

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ΜΑθημα ETY-494 «Ειςαγωγη ςτην ΒιοϊατρικΗ ΜηχανικΗ»

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Ety 494

ETY-494

, ,

. (E-mail: [email protected])

: http://www.materials.uoc.gr/courses/ETY494


Ety 494

  • , ,


Ety 494

ICAM-1

VCAM-1

Mo

LDL

Endothelial Cells

Nox

Lox, MPO

M

Nox

Neointimal SMC

Foam cells

Ox-LDL

MCP-1

Migration

Proliferation

O2-

Smooth Muscle Cells

Fibroblasts

,

Hypertension

Hyperglycemia/Diabetes

Hypercholesterolemia

Oscillatory Shear Stress

TNF

IL-1

Ang II

Weiss et al. AJC 2001;87:25-32


Ety 494

A

B

Fatty-Streak Formation

Endothelial Dysfunction

C

D

Formation of Advanced Lesion

Unstable Fibrous Plaque

Ross R. NEJM 1999;340:115-126


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:

  • LDL , ;


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( 12 dynes/cm2)


Ety 494


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Malek et al. JAMA 282:2035-2042, 1999


Ety 494

Malek et al. JAMA 282:2035-2042, 1999


Ety 494

Malek et al., JAMA 1999;282:2035-2042


Ety 494

Malek et al. JAMA 282:2035-2042, 1999


Ety 494

Signal transduction

Gene expression

Maximum activation

Maximum activation

Activation

Activation

Basal activity

Ras

Basal activity

MCP-1 mRNA

ERK

c-fos mRNA

JNK

min

min

60

120

240

0

180

0

30

60

Chien et al. Hypertension 1998;31:162-169


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2001, , ISBN-10: 0-387-25631-8, ISBN-13: 978-0387-25631-3

Introduction to Bioengineering. Advanced Series in Biomechanics-Vol. 2

Y.C. Fung (Ed.), World Scientific, 2001

ISBN 981-02-4023-6, ISBN 981-02-4398-7 (pbk)

Transport Phenomena in Biological Systems.

George A. Truskey, Fan Yuanand David F.Katz.Pearson Prentice Hall.

ISBN: 0-13-042204-5

Mechanosensing and Mechanochemical Transduction in Extracellular Matrix

Biological, Chemical, Engineering, and Physiological Aspects

Silver, Frederick H.

2006, XVI, 296 p., 145 illus., Hardcover

ISBN-10: 0-387-25631-8, ISBN-13: 978-0-387-25631-3

Tissue Mechanics

Cowin, Stephen C., Doty, Stephen B.

Springer Verlag, 2007, XVI, 682 p., 300 illus., Hardcover

ISBN-10: 0-387-36825-6, ISBN-13: 978-0-387-36825-2

Physics of the Human Body

Irving P. Herman

2007, Springer Verlag

ISBN-10 3-540-29603-4, ISBN-13 978-3-540-29603-4

Vascular Mechanics and Pathology

Thubrikar, Mano J.

2006, XXIV, 496 p., 255 illus., 21 in colour, Hardcover

ISBN-10: 0-387-33816-0, ISBN-13: 978-0-387-33816-3

The Physics of Coronary Blood Flow

Series: Biological and Medical Physics, Biomedical Engineering

Zamir, M.

2005, XVIII, 410 p., 269 illus., 4 in colour, Hardcover

ISBN-10: 0-387-25297-5, ISBN-13: 978-0-387-25297-1

Textbook of Medical Physiology

A.C. Guyton & J.E. Hall

2006, Elsevier, ISBN 0-7216-0240-1, International Edition ISBN 0-8089-2317-X

papers!


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