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Christoph Schramm, Ansgar W. Lohse I. Medizinische Klinik und Poliklinik

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Immunosuppression and PSC. Christoph Schramm, Ansgar W. Lohse I. Medizinische Klinik und Poliklinik Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. Immunosuppression and PSC - background.

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Immunosuppression and PSC

Christoph Schramm, Ansgar W. Lohse

I. Medizinische Klinik und Poliklinik

Universitätsklinikum Hamburg-Eppendorf,

Hamburg, Germany

immunosuppression and psc background
Immunosuppression and PSC - background
  • Up to 10 % of PSC patients have overlapping features with autoimmune hepatitis (secondary AIH)
  • Patients with features of autoimmune hepatitis benefit from immunosuppressive treatment
  • A potential benefit of immunosuppression on early stages of PSC is unknown
hypothesis
Hypothesis
  • Patients with an inflammatory type of PSC / secondary autoimmune hepatitis benefit from immunosuppression with prednisolone/azathioprine
study group project
Study Group project
  • Retrospective study:
    • Collect data on patients with PSC who received immunosuppression not related to IBD
    • Compare long term survival/Ltx to matched control population without immunosuppression
  • Prospective study:
    • Define criteria for immunosuppression in PSC, e.g. ALT > 3x ULN, IgG > 1,2x ULN, histology with mHAI > 6, Scheuer > 2 (portal/periportal activity)
    • Prospectively collect data
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