Jai mata di the mechanism for defocus driven occular growth
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Jai Mata Di The Mechanism for Defocus-driven Occular Growth. The Eye. www.ahaf.org. Lens . Power ( Diopters )focal length (metres) 1 D 1 m 2 D.5 m Convex lens (has a positive power e.g +1.5 D) focal point forms convergent light

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Jai Mata Di The Mechanism for Defocus-driven Occular Growth

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Jai mata di the mechanism for defocus driven occular growth

Jai Mata Di The Mechanism for Defocus-driven Occular Growth


The eye

The Eye

www.ahaf.org


Jai mata di the mechanism for defocus driven occular growth

Lens

  • Power (Diopters)focal length (metres)

    1 D 1 m

    2 D.5 m

  • Convex lens (has a positive power e.g +1.5 D) focal point forms convergent light

  • Concave lens (has negative power e.g -2D) focal point is traced back from diverging light


Jai mata di the mechanism for defocus driven occular growth

http://www.math.ubc.ca/~cass/courses/m309-01a/chu/MirrorsLenses/lenses.htm


Lens accommodation

Lens Accommodation

http://www.sapdesignguild.org/editions/highlight_articles_01/images/accomodation.png


Disorders of optics of eye

Disorders of optics of eye

  • Emmetropia (normal vision)

  • Myopia (short sightedness)

    • Corrected with negative power lens

  • Hyperopia ( Longsightness)

    • Corrected with positive power glasses

  • Presbyopia (age-related changes)

    • Range of accommodation depletion

      • Multifocal or bifocal lens correction


Visual abnormalities

Visual Abnormalities

http://www.merckmanuals.com/professional/sec09/ch099/ch099a.html


Retina rpe choroid

Retina/RPE/Choroid

http://www.maculacenter.com/LightBox/glossaryImages/rpe.jpg


Retinal pigment epithelium

Retinal Pigment Epithelium

Crucial for the maintenance of photoreceptor excitability

  • The main functions of the RPE are the following:

    • (1) Transport of nutrients, ions, and water

    • (2) absorption of light and protection against photooxidation,

    • (3) reisomerization of all-trans-retinal into 11-cis-retinal, which is a key element of the visual cycle,

    • (4) phagocytosis of shed photoreceptor membranes, and

    • (5) secretion of various essential factors for the structural integrity of the retina.


Super project

SUPER PROJECT

  • Nernst– Artificial Membrane

    • Diffusion of Ions

      • Is there a transport of water?

  • Stepper Motor – Servo System

    • Pusing in and pushing out fluid

  • Voltage Clamp

    • Using fixed voltage and determining how much to change to determine a transmission response

  • Fluid Flow

    • Voltage Clamp

    • Chamber

      • Artificial Membrane


Artificial membranes how they are made

Artificial Membranes: How they are made?

  • Usual method is to have a 2 mm diameter hole in teflon sheet between aqueous solutions. Place 1 drop of (say) phospholipid in dodecane on hole and allow it to thin (as one would a soap bubble). Eventually get an optically black lipid bilayer film.

Why use Artificial Membranes?

  • Calibration


Nernst

‘Nernst’


Puddle

‘Puddle’

  • Stepper Motor – Servo System

    • Pushing in and pushing out fluid

Sensor

Engineered by David


Stepper

‘Stepper’

  • Stepper Motor – Servo System

    • Pusing in and pushing out fluid

Engineered by David


Puddle 2 also using an artificial membrane

‘Puddle 2’ - also using an artificial membrane


Rc 50 imaging ussing chamber

RC-50 Imaging Ussing Chamber


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