Week 08. Applied Bioinformatics. Theory I. Protein Sequences Protein Families Protein Domains Computer Learning Garbage in -> Garbage out Prediction based on learned Examples. Protein Sequence. Primary Sequence consisting of 20 amino acids Secondary Structure consists of 3 types
variants and isoforms
Clicking on the Member name (Accession Number)
will provide detailed information about the protein
Define a family of substitution matrices — PAM 1, PAM 2, etc. — where PAM n is used to compare sequences at distance n PAM.
PAM n = (PAM 1)n
Do not confuse with scoring matrices!
Scoring matrices are derived from PAM matrices to yield log-odds scores.
All entries 104