Mapk signaling
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TNFR. ECM. Hormones. Hormones. RTK. Growth Factor Receptors. Rac1. Rac1. GTP. GTP. GTP. GTP. MEK5. MEK 4/7. MEKK 2/3. MEK 3/6. JNK 1/2/3. JNK 1/2/3. ERK 1/2. ERK 1/2. MLK2/3. MLK3. ERK5. TAK1. Src. IRAK. FAK. TAO1,2. Raf1. A-Raf. MNK. PKA. p38. p38. RIP. PKC.

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Presentation Transcript
Mapk signaling

TNFR

ECM

Hormones

Hormones

RTK

GrowthFactorReceptors

Rac1

Rac1

GTP

GTP

GTP

GTP

MEK5

MEK4/7

MEKK2/3

MEK3/6

JNK1/2/3

JNK1/2/3

ERK1/2

ERK1/2

MLK2/3

MLK3

ERK5

TAK1

Src

IRAK

FAK

TAO1,2

Raf1

A-Raf

MNK

PKA

p38

p38

RIP

PKC

PKC

KSR

ASK

ASK

MSK

MSK

PAK

c-Raf

B-Raf

TPL-2

RSK

MEKK4

MEKK4

MEKK3

MEKK3

MEKK1

MEKK1

MEKK1

MEKK2

PKA

PI3K

GPCR

Cytokines

p130CAS

TNF

IL-1

OSM

2009

ProteinLounge.com

TCF/MEF2

MAPKAPK2

Vinculin

Paxillin

Paxillin

POSH

JIP1/2/3

Talin

CDC42

TRAF6

TRAF2

GRB2

TRADD

SOS

Rap1

GPCR

c-Myc

HSF1

c-Fos

STATs

p53

CREB

CREB

TCF

Elk1

CHOP

ATF

c-Jun

NF-kB

NF-kB

GrowthFactors

GrowthFactors

WNK

AC

AC

PLC

PLC

MP1

BCL2

Ras

N

Integrin

a b b a

N

IL-1R

C

SHC

SHC

C

Gb

Gg

DAG

cAMP

MAPK Signaling

cAMP

DAG

MAP3Ks

MAPKs

MEK1/2

Cell MotilityInflammationApoptosisOsmoregulation

Cell ProliferationCell SurvivalTumorigenesisDifferentiationDevelopment

Gene Expression

CellSurvival

C

ApoptosisInflammationTumorigenesis

GeneExpression


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