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Probability and Multiple Trait Inheritance

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Probability and Multiple Trait Inheritance

- All ratios established from a Punnett square, represent probabilities.
- Probability can be thought of as a score out of 1 that indicates the likelihood of an event.
- 0.50 event will occur half of the time
- 1.00 event will occur all of the time

- Product Law: The probability of two or more outcomes occurring is equal to the product of their individual probabilities.

- Thalassemia is an autosomal recessive condition that affects hemoglobin production and can cause anemia in affected persons
H = normal hemoglobinh = thalassemia

- Consider two parents, both heterozygous for thalassemia:
Hh X Hh, what is the probability that they will have an affected child?

- What is the probability of a couple having 3 female children?
- If a couple has 2 children, what is the probability they will have a boy and a girl?
- If their first child is a girl, what is the probability that the next two will be girls?

- The pedigree traces the occurrence of deafness throughout a family.
- If individual IV-2 marries a deaf woman, what is the probability that any of their children will be deaf?

- When analyzing risk based on a pedigree, correctly determining the mode of inheritance is key to making an accurate prediction.
- Determine the mode of inheritance in each case:

- In cocker spaniels:
- black coat colour (B) is dominant to red (b)
- solid colour (S) is dominant to white spotting (s).

- If two dogs, heterozygous for both traits are mated, what is the probability they will have red offspring with white spotting?

- In mice, black coat (B) is dominant to white coat (b) and black eyes (E) are dominant to pink eyes (e).
- A male, heterozygous for both traits, is mated to a pure-breeding recessive female.
- Show the genotypes for each parent
- Show the possible sex cells each parent could produce
- Construct a Punnett square to determine all possible genotypes and phenotypes in the F1 generation.