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CardioSense3D Introduction H. Delingette

CardioSense3D Introduction H. Delingette. Intermediate Evaluation of the CardioSense3D Research Action. Agenda of the day. Introduction to CardioSense3D. Scientific Objectives and Positioning Partnership and organization. What is CardioSense3D ?.

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CardioSense3D Introduction H. Delingette

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  1. CardioSense3DIntroductionH. Delingette Intermediate Evaluation of the CardioSense3D Research Action

  2. Agenda of the day

  3. Introduction to CardioSense3D • Scientific Objectives and Positioning • Partnership and organization

  4. What is CardioSense3D ? • An INRIA Large Initiative Action on cardiac modeling : • Started (officially) in May 2005 • 4 ans duration (evaluated after 2 years) • Transversal to 4 INRIA project teams : • ASCLEPIOS(Medical Image Analysis and Simulation) N. Ayache • MACS (Biomechanics and Numerical Analysis) : D. Chapelle • REO (Fluid Mechanics) : J-F. Gerbeau • SISYPHE (Contrôle and Modeling) : M. Sorine • Supervisor : H. Delingette, • Co-Supervisor : M. Fernandez

  5. CardioSense3D Research Topics Diagnosis Therapy planning Personalization anatomy electro-physiology perfusion & metabolism solid mechanics blood flow Clinical applications Cardiac data Cardiac modeling

  6. Objectives • Build a patient specific heart simulator • Estimate the parameters of this model from observations of the cardiac function, • Develop clinical applications(Cardiac Resynchronisation Therapy, radiofrequency ablation,..) • . Propose models having a low number of parameters

  7. State of the art anatomy perfusion & metabolism electro-physiology blood flow solid mechanics Cardiac modeling • Computational Cardiac Models • ElectroPhysiology : Noble et al. (Oxford), S. Panfilov et al. , O. Dössel (Karlsruhe), Y. Rudy et al. (Wash. Univ. St Louis), Colli-Franzone (Univ. Pavia) • Flow-Biomechanics : C. Peskin (NYU), Quarteroni (EPFL),… • Electro-mechanics : Peter Hunter et al. (Physiome project; Auckland); Andrew McCulloch et al. (UCSD)

  8. State of the art Cardiac data • Cardiac Image Analysis(Geometrical approaches) • Elliott McVeigh et al. (JHU+NIH) • D. Rueckert et al. (Imperial College) and R. Razavi et al. (KCL + Guy’s hospital) • Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas (Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi (Hongkong Univ.)

  9. State of the art Diagnosis Therapy planning • Therapy planning (Generic Models) • D. Noble (Oxford) • A. Mc Culloch (UCSD) • O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah) Clinical applications

  10. Positioning of CardioSense3D • Integrate/Couple 4 physiological phenomena : Electrophysiology, Contraction/Relaxation Mechanics, Arterial Circulation, Perfusion • To propose models having a low number of parameters in order to estimate them from clinical data. • Develop clinical applications (CRT, RF Ablation) based on personalized models

  11. CardioSense3D : Academic / Clinical / Industrial Partnership • Physiology/Control • Sisyphe/Sosso,INRIA • Numerical Analysis • Macs,INRIA • Reo, INRIA • Geometrica,INRIA • Gamma, INRIA • Univ. de Nantes • Pzlen Univ. (Czech Rep.) • LIRMM (Montpellier) • Imaging/Simulation • Asclepios,INRIA • UCL / King’s College (London) • Creatis, CNRS • Clinical Sites • Guy’s Hospital (London) • NIH (Washington) • HEGP, U678 (Paris) • Hopital Henri Mondor (Créteil) • Sunnybrook Health Sciences Center • InParys, Clinique George Bizet • Hopital Bicêtre + Paris XI U. +INSERM (Paris) • Industrial Partners • Philips Research France • ELA Medical • (Siemens)

  12. First Circle Members of CS3D Two different INRIA Research Units : • Sophia-Antipolis • Rocquencourt

  13. INRIA Support • Recruitment of : • P. Moireau (Détachement X-Corps des Telecoms) in 2005 • 4 Phd Thesis : • R. Chabiniok MD (Macs) from Sep. 2007 bourse Cordi • M. Astorino (Reo) from Janvier. 2007 bourse Cordi • F. Billet (Asclepios) from Oct 2006 • R. Djafri (Sisyphe) from 2007 • 3 Engineers : • M. Alba (Macs) 2005-2006 Ingénieur Associé • E. Phe (Macs-REO) 2006-2008 Ingénieur Associé • N. Toussaint (Asclepios) : 2006-2008 Ingénieur Associé

  14. External Support • National Scholarship : • PhD of N. Zemzemi • Philips Medical Systems Paris (Suresnes): • PhD of D. Lepiller (Asclepios) • ELA Medical : • Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard • Siemens Corporate Research • PhD of JM Peyrat • European Health eChild • PhD of T. Mansi • European RTN HaeModel • Phd of N. Diniz Dos Santos • Industrial contracts • PhD of M. Laleg and K. Djabella

  15. Software • Current Development based on 3 software packages : • LifeV (Reo) (www.lifev.org) for CFD and electrophysiology • OpenFEM (Macs) (www-rocq.inria.fr/OpenFEM/ ) for FEM continuum mechanics • Mips and MedInria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop.inria.fr/asclepios/software/MedINRIA/) • Software developed within CardioSense3D : • CardioViz3D (Asclepios) • Heartlab (Macs)

  16. Dissemination Activity • “Digital Heart” DVD (20mn) Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau, Maxime Sermesant

  17. Dissemination Activity • “Digital Heart” Movie • Public release of Software (CardioViz3D) and database (DTI atlas) • Involvements in Conferences (NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News)

  18. Dissemination Activity • “Digital Heart” DVD • Public release of Software (CardioViz3D) and database (DTI atlas) • Involvements in Conferences (ISBI’07, NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News) • CardioSense3D seminars with Paris V university

  19. Dissemination Activity • “Digital Heart” DVD • Public release of Software (CardioViz3D) and database (DTI atlas) • Involvements in Conferences (ISBI’07, NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News) • CardioSense3D seminars with Paris V university • Organisation of workshops (summer school) and conferences (FIMH’09 in Nice) • Apple ARTS Award

  20. Agenda of the day

  21. CardioSense3D Research Topics Diagnosis Therapy planning Personalization anatomy electro-physiology perfusion & metabolism solid mechanics blood flow Clinical applications Cardiac data Cardiac modeling

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