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MAS.S62 FAB 2 4.3.12 Self Replicating Biochemical Systems

MAS.S62 FAB 2 4.3.12 Self Replicating Biochemical Systems. Holliger et. al. Threshold for Life What is the Threshold for Self Replicating Systems? Measurement Theory. Replication Cycle. Parts. +. +. +. Template. +. +. +. Machine. Step 1. Step 2. Step 3. DNA. Error Correcting

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MAS.S62 FAB 2 4.3.12 Self Replicating Biochemical Systems

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  1. MAS.S62 FAB2 4.3.12 Self Replicating Biochemical Systems Holliger et. al

  2. Threshold for Life What is the Threshold for Self Replicating Systems? Measurement Theory Replication Cycle Parts + + + Template + + + Machine Step 1 Step 2 Step 3 DNA Error Correcting Exonuclease (Ruler) Watson Crick .18 nm /sandwalk.blogspot.com/2007/12/dna-denaturation-and-renaturation-and.html http://en.wikipedia.org/wiki/File:Stem-loop.svg How Well Can N Molecules Measure Distance? Probability of Self Replication Number of Nucleotides Threshold length: 691 bp for 50% yield. 315 bp for 10-6 yield.

  3. 220 nt Combinatorics 1:1E132 Library Diversity 1:1E15 Pligase = 1:2E13

  4. Minimum ribozyme length 165 nt 14 nt extension Error rate: 1% Extension rate : 1nt per 153 minutes

  5. Minimum ribozyme length: 20 nt extension Error rate: Extension rate :

  6. 95 nt base extension

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