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Policy review of HIV and TB guidelines for high HIV/TB burden African countries

Policy review of HIV and TB guidelines for high HIV/TB burden African countries. HIV/AIDS Department World Health Organization. WHO 2010 ART guidelines. WHO 2004 Interim Policy on Collaborative TB/HIV Activities. A. Establish NTP-NACP collaborative mechanisms

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Policy review of HIV and TB guidelines for high HIV/TB burden African countries

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  1. Policy review of HIV and TB guidelines for high HIV/TB burden African countries HIV/AIDS Department World Health Organization

  2. WHO 2010 ART guidelines

  3. WHO 2004 Interim Policy on Collaborative TB/HIV Activities A. Establish NTP-NACP collaborative mechanisms • Coordinating bodies for effective TB/HIV activities at all levels • Conduct surveillance of HIV prevalence among TB cases • Carry out joint TB/HIV planning • Monitor and evaluate collaborative TB/HIV activities B. Decrease burden of TB among PLHIV (the "Three I's for HIV/TB") • Establish intensified TB case finding • Introduce INH preventive therapy • Ensure TB infection control in health care and congregate settings C. Decrease burden of HIV among TB patients • Provide HIV testing and counselling • Introduce HIV prevention methods • Introduce co-trimoxazole preventive therapy • Ensure HIV/AIDS care and support • Introduce ARVs

  4. WHO 2010 IPT/ICF Recommendations • Use of four-symptoms screening algorithm to rule out active TB and offer IPT • Four symptoms include cough, fever, weight loss and night sweats • Past history of TB and current pregnancy should not be contraindications for IPT • TST or chest radiography are not required

  5. Estimated 2009 HIV/TB and HIV burden Source : 2010 Stop TB global surveillance report, UNAIDS Report on global AIDS Epidemic 2010

  6. Objectives and Methodology Objectives: Compare national HIV, TB and HIV/TB guidelines for 14 African countries with recently released WHO ART and HIV/TB guidelines Methodology: Main guidelines were collected from the following sources: • National HIV Guidelines • National TB Guidelines • HIV/TB and TB infection control Guidelines Standard abstraction form was used to review recommendations on: • ART initiation criteria • The Three I’s for HIV/TB • The Three I's for HIV/TB monitoring and evaluation indicators

  7. Source : National HIV, TB and HIV/TB Guidelines * Published guidelines, Drafts, Preliminary drafts

  8. ART initiation criteria in people with HIV All figures in cells/mm3, Guidelines in white are similar to WHO recommendations. * Nigeria's TB and HIV/TB guidelines and Zimbabwe's HIV/TB guidelines recommend ART for people with HIV and TB at CD4 count < 350 cells/mm3

  9. ART initiation for asymptomatic people 2010 WHO Recommendation : CD4 count < 350 cells/mm3 ≤ 350 Kenya, Lesotho, Malawi,Namibia, Nigeria, Swaziland, Zambia, Zimbabwe ≤ 250 Botswana, Mozambique, Uganda ≤ 200 Ethiopia, South Africa, Tanzania CD4 Count

  10. ART initiation for people with HIV and TB 2010 WHO Recommendation : ART irrespective of CD4 count • Zambia recommends ART at CD4 count > 350 cells/mm3 if any other stage III or IV illnesses • Ethiopia recommends ART for all extrapulmonary and disseminated TB patients

  11. ART initiation for pregnant women with HIV 2010 WHO Recommendation : CD4 count < 350 cells/mm3 • Malawi, under Option B+, recommends lifelong ART for all pregnant women irrespective of CD4 count

  12. Co-trimoxazole prophylaxis 2006 WHO Recommendation : CD4 count < 350* cells/mm3 or WHO stage 3 or 4 CD4< 200 Cells or WHO Stage 3 or 4 Botswana All HIV positives Kenya, Malawi, Swaziland CD4< 200 Cells or WHO Stage 2, 3 or 4 South Africa Different guidelines followed by different countries CD4< 250 Cells or WHO Stage 2, 3 or 4 Uganda CD4< 350 Cells or WHO Stage 2, 3 or 4 Mozambique, Tanzania,Zambia, Ethiopia**,Zimbabwe CD4< 350 Cells or WHO Stage 3 or 4 Lesotho, Namibia, Nigeria *Countries may choose to adopt a CD4 threshold of < 200 cells/mm3 **Source: Ethiopia's Co-trimoxazole prophylaxis guidelines, 2006

  13. National policies for HIV, TB and HIV/TB, and the Three I's for HIV/TB NAP – National ART Policy, NTP – National TB Policy, ICF – National intensified TB case finding guidelines, IPT – National IPT guidelines, IC – TB infection control guidelines, OI – National guidelines on management of HIV-related opportunistic infections Note: * 2011 NTP for Swaziland recommends Three I's for HIV/TB but do not mention any guidelines ** These guidelines do not recommend IPT

  14. Countries recommending the Three I’s for HIV/TB * Zambia: Preliminary draft on ICF guidelines recommends IPT

  15. Nigeria Ethiopia Uganda LEGEND Kenya IPT Initiation criteria Tanzania Malawi IPT not recommended Symptom-based Zambia Mozambique Symptom-based + sputum Zimbabwe Namibia smear microscopy + chest X-ray Botswana Symptom-based + sputum smear microscopy + chest X-ray + TST Swaziland South Lesotho Africa TB screening criteria for IPT 2010 WHO Recommendation : Symptom-based screening Note: The map shows IPT initiation criteria recommended by the most recent guidelines for a country

  16. TB exclusion criteria for IPT initiation 2010 WHO Recommendation : Four-symptom screening for cough, fever, weight loss and night sweats BOTSWANA NTP 2007 NAMIBIA* NAP 2010 Enlarged glands KENYA OI 2008 NTP 2009 Diarrhoea WHO recommendation SOUTH AFRICA IPT 2010 ETHIOPIA HIV/TB 2008 ZAMBIA IPT 2010 MALAWI NAP 2011 NIGERIA*** NAP 2010 SOUTH AFRICA NAP 2010 Coughing blood Coughing blood Chest X-ray MOZAMBIQUE NAP 2010 TANZANIA** NAP 2009 Sputum smear Sputum production Chest pain Chest pain Enlarged glands KENYA NAP 2011 Chest X-ray Loss of appetite Loss of appetite Loss of appetite SWAZILAND NAP 2010 Abnormal chest findings Swelling Chest pain LESOTHO NAP 2007 UGANDA NTP 2010 Chest pain Chest pain Shortness of breath Shortness of breath Coughing blood Shortness of breath Enlarged lymph nodes Enlarged lymph nodes Sputum smear TST Night sweats Night sweats Night sweats Night sweats Night sweats Night sweats Night sweats Sputum smear Chest X-ray Weight loss Night sweats Weight loss Weight loss Weight loss Weight loss Weight loss Weight loss Weight loss Chest X-ray Night sweats Fever Fever Fever Fever Fever Fever Fever Fever Fever Cough Cough Cough Cough Cough Cough Cough Cough Cough Cough Cough * 2011 TB guidelines for Namibia recommend enlarged lymph nodes as an additional symptom ** 2006 TB guidelines for Tanzania recommend chest pain as an additional symptom *** 2008 IPT guidelines for Nigeria recommend weight loss as an additional symptom, 2010 NTP guidelines do not recommend chest X-ray and sputum smear microscopy

  17. Exceptions to WHO recommendations on IPT 2010 WHO Recommendation : IPT to all irrespective of previous history of TB or current pregnancy and IPT with ART also recommended • Botswana and Mozambique – No IPT initiation in pregnancy • Botswana and Tanzania – IPT not for children • South Africa – IPT with ART is a conditional recommendation • Lesotho – IPT offered to TB-exposed HIV infected children and at pilot sites where active TB can be ruled out • Malawi – Stop IPT when patient is started on ART • Kenya and Swaziland– IPT provided in clinics with TB screening, adherence counselling and patient follow-up services • Uganda – IPT provided in institutions with adequate human resources, infrastructure, and equipment and logistics

  18. Indicators for monitoring and evaluating performance on the Three I’s for HIV/TB ICF IPT Yes No Yes No Lesotho Ethiopia Malawi Mozambique Namibia Nigeria Swaziland Uganda Zambia Botswana Kenya South Africa Tanzania Zimbabwe Botswana Ethiopia Lesotho Mozambique Namibia South Africa Swaziland Uganda Kenya Malawi Nigeria Tanzania Zambia Malawi, Namibia, Nigeria, Swaziland and Uganda have indicators for TB infection control

  19. Limitations • Guidelines may be outdated and/or in the process of being updated • Written policies may not reflect programme implementation • Other guidelines covering ART and the Three I’s for HIV/TB may exist - Infection control guidelines - Monitoring and evaluation guidelines

  20. Conclusion • Many countries follow the recently released WHO guidelines • - Asymptomatic patients – 8 countries • - HIV/TB co-infected people – 7 countries • - Pregnant women – 10 countries • Malawi recommends lifelong ART for pregnant women irrespective of CD4 count (Option B+) • Almost all countries have recommendations on the Three I’s for HIV/TB • CPT initiation criteria differs widely across countries • ICF and IPT guidelines specified in both NAP and NTP for many countries • Many countries have ICF and IPT indicators • Room for improving monitoring and evaluating progress onTB infection control

  21. Recommendations ART policy • Revise ART eligibility criteria where necessary IPT policy • Adapt policies to recommend IPT for all, including pregnant women, previous TB patients and PLHIV on ART • Simplify criteria for IPT initiation Monitoring and evaluating of the Three I's for HIV/TB • Include indicators on ICF and IPT in National ART Guidelines • Adapt and implement indicators for TB infection control

  22. Thank you…

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