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Zinc Fingers. By Jeffrey Mah Biotechnology 2009-2010. Definition:. A type of small protein with 20-30 amino acids Bonded to a zinc ion Play essential roles in DNA recognition. Found in:. Thousands of other proteins Plants Animals BUT not bacteria . Function/Regulation:.

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Zinc fingers
Zinc Fingers

By Jeffrey Mah

Biotechnology 2009-2010


Definition
Definition:

  • A type of small protein with 20-30 amino acids

  • Bonded to a zinc ion

  • Play essential roles

  • in DNA recognition


Found in
Found in:

  • Thousands of other proteins

  • Plants

  • Animals

  • BUT not bacteria


Function regulation
Function/Regulation:

  • The expression of genes

  • Assembly of viruses

  • Reverse transcription

  • Nucleic acid recognition

  • Stabilizes and solidifies DNA and RNA


Structure
Structure:

  • Main structure:

    • 1 tetrahedron

    • - 2 Cysteines

    • - 2 Histidines

    • - 1 zinc ion


Structure1
Structure:

The other 15-25 amino acids all face more-or-less outwards, and can be used for various functional tasks


Significance
Significance:

  • Tiny protein that helps with DNA related work

  • Researchers are currently trying to design artificial zinc fingers with different specificities


Work cited
Work Cited

  • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html

  • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_2.html

  • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_3.html

  • http://upload.wikimedia.org/wikipedia/commons/7/79/Zinc_finger_DNA_complex.png


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