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UK Bioinformatics Forum: Successful Strategies in Bioinformatics Business

UK Bioinformatics Forum: Successful Strategies in Bioinformatics Business. “Strategic Advantages for Development and Commercialisation of a Proprietary Bioinformatics Database Platform in the Asia Pacific Region” ” DTI Conference Centre, London March 8 th 2005 By: Dr. Arif Anwar

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UK Bioinformatics Forum: Successful Strategies in Bioinformatics Business

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  1. UK Bioinformatics Forum: Successful Strategies in Bioinformatics Business

  2. “Strategic Advantages for Development and Commercialisation of a Proprietary Bioinformatics Database Platform in the Asia Pacific Region”” DTI Conference Centre, London March 8th 2005 By: Dr. Arif Anwar Vice President, Synamatix

  3. Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities

  4. Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities

  5. Core Competencies with Asia Pacific Rim Forum Science Innovation Summit 2003

  6. Projected Core Competencies with Asia Pacific Rim Forum Science Innovation Summit 2003

  7. Malaysia as a case study…

  8. Malaysia as a case study…bioinformatics business • Stringent IP enforcement and protection • Attractive government incentives and support • Low start-up and “burn rate” costs • Excellent corporate and physical infrastructure • Skilled, yet cost effective labour force • Compelling location for Bio-business • Via realising funding opportunities • Establishing new companies • Off-shoring development or partnerships/collaborations

  9. Annual Budget 3-year Budget 5-year Budget Pacific Rim Forum Science Innovation Summit 2003 Increasing government investment VISION 2020 The Malaysian Government has recently increased its spending budget to USD$7.9 Billion to develop the Biotechnology sector up to 2010

  10. Synamatix: Success and Support go hand in hand Public and Private Sector Funding IT Infrastructure, Incentives and Grant Schemes *Global Strategic Partnerships *Diversification & Market Penetration

  11. Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities

  12. Leveraging strategic regional advantages • Cost • Environment • Cutting edge - High value IP - SynaBASE™ - universal • Very High potential ROI and IRR • Achieved significant development and commercialisation initiation using seed funding • Prudent financial management • Tracked for early profitability • High investor return

  13. Synamatix progress

  14. A proprietary database platform technology Data repository External Packages Internal software External development Internal development

  15. Current and future Applications Comparative Genomics Chip design Personalised Medicine and Genomics Sequence Mining Mapping Motifs Proteomics Annotation Clustering & Assembly Phylogenetics

  16. Unique Value Propositions X5

  17. Patterns and structures • Finds, Stores, Relates & Structures • PATTERNS, • not FLAT FILES • No rules or training sets

  18. *patents pending

  19. 1. Patterns and structures 2. Significance & Frequency SynaBASE automatically learns and maintains the significance and entropy of patterns and data

  20. Relying on frequency alone is inadequate… The elephant and the giraffe walked up the mountain A graph showing Frequency of  “string (word)” patterns in a sentence does not reflect meaning The elephant and the giraffe walked up the mountain A graph showing Probabilities of predicting Precessor and Successor Characters/events (string Significance) reflecting meaning

  21. Patterns and structures • SIGNIFICANCE and Frequency • 3. Scale and 4. Speed • Unique method for structuring data leads to • Ultra-high-throughput applications becoming routinely accessible

  22. 10 Genome 10 9 Genome 9 8 Genome 8 7 Genome 7 Size of pattern database 6 Genome 6 5 Genome 5 4 Genome 4 3 Genome 3 2 Genome 2 1 Genome 1 2 4 6 8 10 Number of Human genome copies

  23. 10 9 8 Size of pattern database 7 6 5 4 Genome 10 Genome 9 Genome 8 Genome 7 3 Genome 6 Genome 5 Genome 4 2 Genome 3 Genome 2 1 Genome 1 2 4 6 8 10 Number of genomes

  24. Analysis speed scales at logn base 2 Speed milliseconds 900 800 Conventional 700 600 SynaBASE 500 400 300 200 100 Size of database giga bp 1 10 100 1000

  25. All Prokaryotes All genomes!! All variants!! All Multiples…. All Eukaryotes Human Virus Mouse Ultra-high-throughput analysis 1stPersonalised medicine data mining capability All Plants Sequence data

  26. UHT Comparative genomics in minutes

  27. Patterns and structures • SIGNIFICANCE and Entropy • Speed and 4. Scale • 5. Future proof • A non brute force investment, • hardware independence leads to novel applications • or challenging research projects

  28. Agenda • Asia and Bioinformatics – Strategic and Tactical benefits • 2. Case Study: Synamatix • 3. Partnering Opportunities

  29. Technology Business Comparative genomics Personal genome data Personalised medicine Ultra-high-speed genomic analysis Co-research and publication OEM and embedding Distributors – multi-directional Co-technology leverage/development MGRC research and distribution Core competence sharing

  30. Summary • Asia represents a compelling dual opportunity • Regional advantages of establishing or investing in Bioinformatics operations • Cost • Incentives • Market opportunity • Synamatix case study • Innovative, seminal bio-database platform • Offering strategic advantages of Asia based operations • Low burn rate • High ROI • High IRR

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