Model of SOS-induced mutagenesis in bacteria
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Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation. By Mostafa Abo Elsoud (National Research Center, Egypt). Supervised by Marina L yashko Svetlana Aksenova. Laboratory of Radiation Biology (LRB), JINR, Russia.

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Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation

By

MostafaAboElsoud

(National Research Center, Egypt)

Supervised by

Marina Lyashko

Svetlana Aksenova

Laboratory of Radiation Biology (LRB), JINR, Russia.


  • The SOS response in Escherichia coli bacteria is a set of inducible physiological reactions that help a cell to survive after the treatment with various DNA-damaging agents, such as ultraviolet, ionizing radiation and some chemicals.

  • More than 40 genes are induced in response to DNA damage as part of the SOS regulonin Escherichia coli.

  • SOS repair may result in SOS mutagenesis due to the inhibition of the proofreading activity of the epsilon subunit of DNA Pol III.


Cyclobutane pyrimidinedimers (CPD)

And

pyrimidinepyrimidone photoproduct (6-4 PP)

Lex A

UV

RecA

Umuc, UmuD, DinI

SOS gene box

RecA*

Mechanism of SOS repair system activation


ssDNA+RecA+ATP

Mechanism of

SOS repair system

RecA*

DinI

LexA

UmuD

UmuD’

.

umuC

umuD

dinI

.

UmuD2

UmuDD’

UmuD’2

UmuC

UmuD2C

UmuD’2C

UmuDD’C

Pol V




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