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Network of Excellence Integrating Genomics, Clinical Research and Care in Hypertension InGenious HyperCare

InGenious HyperCare. Network of Excellence Integrating Genomics, Clinical Research and Care in Hypertension InGenious HyperCare. InGenious HyperCare : Partners. InGenious HyperCare. Italy 1. Ist. Auxologico It., Milan (A. Zanchetti) 2. Un. Milano Bicocca (G. Mancia)

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Network of Excellence Integrating Genomics, Clinical Research and Care in Hypertension InGenious HyperCare

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  1. InGenious HyperCare Network of Excellence Integrating Genomics, Clinical Research and Care in Hypertension InGenious HyperCare

  2. InGenious HyperCare : Partners InGenious HyperCare Italy 1. Ist. Auxologico It., Milan (A. Zanchetti) 2. Un. Milano Bicocca (G. Mancia) 3. Un. Milano (D. Cusi, F. Magrini) 4. Un. Brescia (E. Agabiti-Rosei) 5. Un. Roma-Sapienza (M. Volpe) 6. Un. Padova (E. Casiglia) 7. Un. Vita Salute, Milano (G. Bianchi) France 8. INSERM Paris (S. Laurent) 9. CHU Nancy (F. Zannad) United Kingdom 10. Un. Glasgow (A. Dominiczak) 11. Un. Manchester (A. Heagerty) 12. Un. Leicester (B. Williams) Belgium 13. KU Leuven (J. Staessen) Netherlands 14. Un. Maastricht (H. Struijker-Boudier) Germany 15. Charité, Berlin (T. Unger, F. Luft) 16. MH Hannover (H. Haller) 17. WWU Münster (E. Brand) Spain 18. HCU Valencia (J. Redón) 19. FIMA Navarra (J. Diez) 20. Hosp. 12 Octubre, Madrid (L. Ruilope) 21. HCP Barcelona (A. Coca) Sweden 22. Un. Lund (O. Melander) Finland 23. Un. Helsinki (S. Tuomilehto) Poland 24. Med. Un. Gdansk (K. Narkiewicz) 25. Jagellonian Med. Un. Cracow (K. Kawecka) Czech Rep. 26. IKEM, Prague (R. Cifkova) 27. Charles Un. Pilsen (J. Filipovsky) Switzerland 28. Un. Lausanne (M. Burnier) Russia 29. RAMS, Novosibirsk (Y. Nikitin) China 30. IH Shanghai (J. Wang) SME 31. Mosaiques (H. Mischak) 32. CF Consulting (C. Finocchiaro) 1473 Z

  3. InGenious HyperCare General Goals Integrating complementary but still fragmented experiences in Studying the physiological mechanisms of blood pressure control and hypertension development Phenotyping initiation and progression of organ damage Exploring genetics, genomics and proteomics of proneness to hypertension and hypertension-related cardiovascular disease

  4. InGenious HyperCare Specific Goals To create large common databases of subjects with and without hypertension, with and without hypertension-related cardiovascular and renal disease To establish joint platforms for phenotyping, genotyping, proteomic studies and statistical analyses To initiate coordinated programmes of research activities

  5. InGenious HyperCare Joint Research Packages A : Mechanomics of Hypertension The first group of JRPs (A1,A2,A3) proposed as joint research activity of the Network aims at identifying genetic, genomic and proteomic markers of disturbances in the major physiological mechanisms controlling blood pressure, as potential indicators of the risk of becoming hypertensive, thus indentifying those subjects genetically prone to hypertension upon whom to concentrate preventive measures A1. Genetics and Genomics of Autonomic Cardiovascular Control ( Coordinators G. Mancia and A. Zanchetti ) A2. Genetics, Genomics and Proteomics of Oxidative Stress and Inflammation ( Coordinators A. Dominiczak and H. Haller ) A3. Genetics and Genomics of Sodium Homeostasis in Hypertension and LVH ( Coordinators J. Staessen and K. Kawecka-Jaszcz )

  6. InGenious HyperCare Joint Research Packages B: Mechanomics of Hypertension - Related Cardiovascular Disease The second group of JRPs (B1, B2, B3) aims at jointly approaching the indentification of the genetic, genomic and proteomic markers of the risk of a hypertensive patient to develop a specific type of event (stroke, renal disease, heart failure), thus identifying those subjects in greatest need of therapeutic intervention. B1. Genetics and Genomics of Hypertension and Stroke (Coordinators A. Dominiczak and A. Zanchetti ) B2. Genetics, Genomics and Proteomics of Hypertension Associated with Renal Disease (Coordinators H. Hallerand J. Redón) B3. Genetics, Genomics and Proteomics of Heart Failure in Hypertension (Coordinators J. Diez and F. Zannad)

  7. InGenious HyperCare DELIVERABLES ACHIEVED IN THE FIRST 18 MONTHS D.SE1.1 Web site (P1-AU) – January 2007 D.A3.1.1 Study protocol and manual of operations (P13 K.U.Leuven) – January 2007 D.A1.1.1 Study protocol and manual of operations (P1-AU) – March 2007 D.A2.1.1Study protocol and manual of operations (P10-UGLA) – March 2007 D.B1.1.1. Study protocol and manual of operations (P1-AU) – March 2007 D.B2.1.1Study protocol and manual of operations (P18-FIHCUV)- March 2007 D.B3.1.1. Study protocol and manual of operations (P9-CHU NANCY)- March 2007 D.SE1.2 Project presentation (P1 AU)- April 2007 D.SE1.3 Plan for using and disseminating knowledge (P1-AU)- June 2007 D.MA1.1 JPA over the next 18 months (P1-AU) November 2007 D.I.2.1 Activation of genotyping platforms (P1-AU) February 2008 D.I.4.1 Protocols and preliminary observations of animal studies (P19-FIMA) April 2008

  8. InGenious HyperCare Integrating Activities Web site (G. Parati) Development of joint electronic communication and data sharing network (G.Parati) Establishing research platforms within and across JRPs Quality control Staff mobility and exchange

  9. InGenious HyperCare

  10. InGenious HyperCare

  11. InGenious HyperCare WP SE 1 SPREADING OF EXCELLENCE / 1 Task 1 Training At the project start, the Consortium collects and integrate training material and make it available on the web via the Network’s communication infrastructure, regularly updated. Researchers give seminars/lectures either as part of their teaching activity or as part of events/visits. A devoted training plan is developed by the NSC with the support of the European Society of Hypertension, and with the Spread of Excellence Committee. By month 18, yearly training activities open to interested investigators NoE, are started. Postgraduate schools and doctoral courses at the participating universities interact with young investigators, spreading the excellence of the Network by basing teaching on the most updated technologies of the Network platforms and data base.

  12. InGenious HyperCare WP SE1 SPREADING OF EXCELLENCE / 2 • Task 2 Dissemination • dissemination plan produced by month 6 and further developed after full integration of the phenotyping, genotyping and proteomic platforms, according to technological and scientific advances in the area. • press conferences and press releases to inform the scientific community and the general public • web site launched by month 3 • project presentation in English prepared by month 6, accessible to non-specialist • yearly international workshop co-located with a leading international conference to establish a forum for discussion and to reach critical mass to run a self-sustained international conference • participation in selected conferences and workshops, focusing on the topics relevant to the Network, with publication of papers

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