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Malaria

Malaria. Presented by, Mr. Jilo P Thomas Nursing Tutor College of Nursing Kishtwar. Name means “bad air”- A life-threatening parasitic disease 40% of the world’s population is at risk 90% of the deaths due to Malaria occur in Sub-Sahara Africa, mostly among young children.

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Malaria

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  1. Malaria Presented by, Mr. Jilo P Thomas Nursing Tutor College of Nursing Kishtwar

  2. Name means “bad air”- • A life-threatening parasitic disease • 40% of the world’s population is at risk • 90% of the deaths due to Malaria occur in Sub-Sahara Africa, mostly among young children. • Around 400-900 million people are affected • At least 2.7 million deaths annually. • It is one of the major public health concerns

  3. Anopheles mosquitoes as vectors • what use is the vector genome sequence? • what is the ecology of Anopheles? • investigate the specificity of the vector as related to individual Plasmodium spp. using sequence data • what is the vector geographic distribution with regards to Plasmodium infection? • what are eradication strategies, and implications on Plasmodium genome evolution?

  4. Development of Malaria vaccines • why are they so difficult to develop? • what is relationship to Plasmodium lifecycle? • what epitopes do the vaccines target & why? • what are the model organisms for vaccine development, and why? • most new vaccines are recombinant. Why? • can human vaccines work in other hosts? How does this relate to the vaccine targets?

  5. Life Cycle of Malarial Parasite

  6. Malaria as a global problem (ethics) • how does economic and cultural development impact the incidence and/or severity of malaria? • who pays for malaria? • money • time • effort • why should we be concerned if it's not in the U.S.? • vaccination programs • New Chemotherapy • what are difficulties in implementing vaccination programs? • who determines who gets vaccinated? • who gets vaccinated?

  7. Conclusion • Malaria is a global problem that lends itself to a multilayered investigation with bioinformatics as a major component. • The wealth of materials and the ongoing sequencing process make it possible to continually expand the investigation to encompass increasingly sophisticated students.

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