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马长生 董建增 刘兴鹏 喻荣辉 龙德勇 首都医科大学北京安贞医院心内科 Department of Cardiology , Beijing Anzhen Hospital,

慢性房颤“ 203L ” 导管消融策略 Experience of “203L” ablation strategy on Chronic Atrial Fibrillation ( CAF ). 马长生 董建增 刘兴鹏 喻荣辉 龙德勇 首都医科大学北京安贞医院心内科 Department of Cardiology , Beijing Anzhen Hospital, Capital Medical University , Beijing, China. 探索慢性房颤最佳消融策略

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马长生 董建增 刘兴鹏 喻荣辉 龙德勇 首都医科大学北京安贞医院心内科 Department of Cardiology , Beijing Anzhen Hospital,

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  1. 慢性房颤“203L”导管消融策略Experience of “203L” ablation strategy on Chronic Atrial Fibrillation(CAF) 马长生 董建增 刘兴鹏 喻荣辉 龙德勇 首都医科大学北京安贞医院心内科 Department of Cardiology,Beijing Anzhen Hospital, Capital Medical University,Beijing, China

  2. 探索慢性房颤最佳消融策略 Exploring The Optimal Ablation Strategy On CAF --- Anzhen Experience 2004-2005 CPVI + CTI 2005-2006 CPVI + CTI + CFAE Roof/MI abl. limited to related AT documented 2007-2008 CPVI +Roof +MI +CTI +CFAE(stepwised) to know the mechanism of every AT to persure termination by abl. 2008- CPVI + Roof + MI + CTI (203L) PVI+bi-directional linear block no extra CFAE ablation no mapping before 203L endpoints achieved(even AT) not to persure termination by abl. Iso/burst stim. to induce AT

  3. 慢性房颤203L消融策略 203L approach on CAF • 203L消融步骤: • PVIs -------------------------- “20” • Roof、MI、CTI ---------- “3L” • 电复律,窦性心律下保证PVI和线性阻滞 • Iso、Burst刺激 • 标测消融诱发的规律心动过速(房颤SVC隔离) Sang CH,Heart Rhythm, 2010, 7: S332

  4. 病例58M 慢性房颤

  5. 消融:CPVA, roof-line, MAI, CTI, Cs

  6. DC-CV

  7. RSPV RIPV LSPV LIPV

  8. Roof-line block

  9. 起搏CSp S-ABLd 130ms

  10. 起搏CSd S-ABLd 145ms

  11. 起搏ABLd S-CSd 150ms CSp早于CSd

  12. 起搏CSp S-LRA 144ms

  13. 可1:1 夺获最短 S1S1 刺激

  14. 慢性房颤203L策略有助于发现各种可能存在的少见房性心律失常慢性房颤203L策略有助于发现各种可能存在的少见房性心律失常

  15. 慢性房颤逐步消融中规律房速机制 Mechanisms of ATs During Catheter Abl. of CAF By Stepwised Approach • 和PV及 Roof、MI、CTI无关者(<10%) • SVC • 局部折返 • 局灶房速 • 局部CFAE • SVT

  16. Activation Mapping Only After Endpoints/203L Achieved 山重水复疑无路,柳暗花明又一村

  17. 慢性房颤消融策略 Ablation Strategy On CAF Ablations Strategy CFAE* Stepwised # 203L@ Defragmentation no yes no CFAE yes no no PVI no yes yes Linear block no yes yes * Nademanee K. JACC, 2004,43: 2044-2053 # Haissaguerre M. JCE, 2005;16:1125-37 @ Sang CH. Heart Rhythm, 2010, 7: S332

  18. 慢性房颤203L策略符合生理

  19. 203L Is Physiologic

  20. 203L Approach For CAF --- a fixed, simple, physiologic approach 55F CAF 4 years CHF 6 months LVED:58mm EF:28% Ablations: PVIs 、 Roof、MI、CTI (203L)

  21. MV Doppler 6 Months Post Ablation E A 99cm/s 77cm/s

  22. 6 months post ablation 3 days post ablation

  23. STEPWISE---追求消融中止房颤(扑)的激进碎裂电位消融是有害的STEPWISE---追求消融中止房颤(扑)的激进碎裂电位消融是有害的

  24. 房间隔过度消融的危害 Possible harmful ablation

  25. 房间隔过度消融的危害 Possible harmful ablation P QRS A V LAA激动显著延迟率:11% Jiang CX, PACE, 2010; 33: 652-660

  26. 慢性房颤驱动:垂帘听政 Criteria for focal firing during afib. on • 房颤驱动通常不是最快频率电位部位 • 房颤时最快频率电位部位通常不是驱动灶,相反是被动表现

  27. 水心如镜面 微风荡涟漪

  28. 203L策略 redo容易

  29. 初次203L 策略消融者Redo容易

  30. 慢性房颤203L策略是否经得起考验

  31. 慢性房颤:203L VS. 逐步消融策略 随机对照研究---方法 • 203L 策略 • 初始消融: PVI + ROOF + MI + CTI • 电复律 • 保证实现203L终点 • 标测消融诱发的心动过速 • 逐步消融 • 初始消融: PVI + ROOF + MI + CTI • CFAE 消融 • 标测和消融所有规律房速直至窦性 • 保证PVI 和所有径线双向阻滞 每3月UCG及Holter 电话心电图 >2次/周 随时进行ECG检查 每月电话随访 中卫莱康

  32. 慢性房颤:203L VS. 逐步消融策略 随机对照研究---结果 • 已连续入组CAF112例,计划入选150例 • 203L组:61 • Stepwise组:51 • 67例完成术后3月随访 • 203L组38例,窦性心律维持率71%(27/38) • Stepwise组29例,窦性心律维持率69(20/29) • 203L之外的机制<15% • 复发者85%(17/20)为规律房速 • Redo 8例,全部成功

  33. 慢性房颤:203L VS. 逐步消融策略 随机对照研究---结果

  34. 203L策略挑战:终点不充分

  35. LSPV LIPV LAA MA 3 dimentional characteristics of the ridge at the LIPV end of MI

  36. IVC-Tricuspid Isthmus (CTI)

  37. CTI pouch

  38. IVC-Tricuspid Isthmus (CTI)

  39. 203L初始消融后窦性心律不能保持(< 5%) • 取决于初始消融的效率 • 取决于患者自身机制 • 胺碘酮静脉应用有效 • 消融前胺碘酮负荷量帮助更大

  40. 慢性房颤203L消融策略 203L approach on CAF • 203L策略特点 • 方法固定 • 符合生理 • 结果可重复 • 不需要消融CFAE/或碎裂电位 • 不需要标测 • 不需要直接消融中止 • 一次成功率高 • 再次消融容易

  41. 谢谢

  42. 结论 慢性房颤基于PVI和线性阻滞策略碎裂电位消融是 画蛇添足 谢谢

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