Cardiovascular disease genetic alterations and gene therapy
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CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY. BY: Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer. PROBLEM. With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?.

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Cardiovascular disease genetic alterations and gene therapy

CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY

BY:

Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer


Problem
PROBLEM THERAPY

  • With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?


Problem1

Risk Factors For CVD THERAPY

Tobacco Use

Hypertension

High Levels of Cholesterol

Physical inactivity

Diabetes

High Triglyceride Levels

Obesity

Psychological & Social Factors

Heredity

Aging

Male

Ethnicity

Syndrome X

PROBLEM


Problem2

Risk Factors For CVD THERAPY

Tobacco Use

Heredity

High Levels of Cholesterol

Physical Inactivity

Diabetes

High Triglyceride Levels

Obesity

Psychological & Social Factors

Hypertension

Aging

Male

Ethnicity

Syndrome X

PROBLEM


Background information
BACKGROUND INFORMATION THERAPY

  • Facts about Cardiovascular Disease

    • Mortality of CVD is 1½ times that of cancer

    • Quality of life diminished for 25% of population

    • Strokes account for 1/6 of all CVD hospitalizations

    • Congestive heart failure is most frequent cause of hospital visits by people over 65

    • Impact is far reaching


Possible solutions
POSSIBLE SOLUTIONS THERAPY

  • Gene Transfer

  • Modification

    • Genetically defective contractile proteins

    • Myocardial cells

    • Cardiac protein profile to rebuild muscle

    • Enhance contractility

  • Replacement

    • Artherosclerosis prevention

  • Regrowth

    • Alternatives to invasive surgery

    • Repair damaged tissue and improve heart function after infarction


Best solution
BEST SOLUTION THERAPY

  • Regrowth with the use of Stem Cells

    • Proven successful on mice

    • Testing on non-human primates to begin

    • Angiogenesis “opens up” blocked vessels

    • Effectiveness on cardiac muscle


Conclusion
CONCLUSION THERAPY

  • With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?

  • Push for gene therapy with stem cells on humans


References
REFERENCES THERAPY

  • Core Concepts In Health, by Insel & Roth pgs. 10, 428-436, 446, 454, 483

  • Primary site – CVD/gene therapy paper http://oak.cats.ohiou.edu/~ed170793/paper.htm

  • Common viriants of most human genes www.ornl.gov/hgmis/publicat/hgn/v10n1/13lander.html

  • Understanding DNA variations www.ornl.gov/hgmis/publicat/hgn/v10n1/06snps.html

  • Explaining the human genome project www.nhgri.nih.gov/Policy_and_public_affairs/Communications/Publications/Maps_to_medicine/about/html


References1
REFERENCES THERAPY

6. Angiogenesis www.bioportfolio.com/news/leaddiscovery_10.htm

7. Stem cells www.genome.gov/page.cfm?pageID=10000345

8. Gene clues and CVD www.the-aps.org/press_room?release2-19-02.htm

9. Use of stem cellls on mice www.seniors.gov/articles/0401/heartattack


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