cardiovascular disease genetic alterations and gene therapy
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CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY. BY: Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer. PROBLEM. With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?.

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cardiovascular disease genetic alterations and gene therapy

CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY

BY:

Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer

problem
PROBLEM
  • With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?
problem1
Risk Factors For CVD

Tobacco Use

Hypertension

High Levels of Cholesterol

Physical inactivity

Diabetes

High Triglyceride Levels

Obesity

Psychological & Social Factors

Heredity

Aging

Male

Ethnicity

Syndrome X

PROBLEM
problem2
Risk Factors For CVD

Tobacco Use

Heredity

High Levels of Cholesterol

Physical Inactivity

Diabetes

High Triglyceride Levels

Obesity

Psychological & Social Factors

Hypertension

Aging

Male

Ethnicity

Syndrome X

PROBLEM
background information
BACKGROUND INFORMATION
  • Facts about Cardiovascular Disease
    • Mortality of CVD is 1½ times that of cancer
    • Quality of life diminished for 25% of population
    • Strokes account for 1/6 of all CVD hospitalizations
    • Congestive heart failure is most frequent cause of hospital visits by people over 65
    • Impact is far reaching
possible solutions
POSSIBLE SOLUTIONS
  • Gene Transfer
  • Modification
    • Genetically defective contractile proteins
    • Myocardial cells
    • Cardiac protein profile to rebuild muscle
    • Enhance contractility
  • Replacement
    • Artherosclerosis prevention
  • Regrowth
    • Alternatives to invasive surgery
    • Repair damaged tissue and improve heart function after infarction
best solution
BEST SOLUTION
  • Regrowth with the use of Stem Cells
    • Proven successful on mice
    • Testing on non-human primates to begin
    • Angiogenesis “opens up” blocked vessels
    • Effectiveness on cardiac muscle
conclusion
CONCLUSION
  • With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?
  • Push for gene therapy with stem cells on humans
references
REFERENCES
  • Core Concepts In Health, by Insel & Roth pgs. 10, 428-436, 446, 454, 483
  • Primary site – CVD/gene therapy paper http://oak.cats.ohiou.edu/~ed170793/paper.htm
  • Common viriants of most human genes www.ornl.gov/hgmis/publicat/hgn/v10n1/13lander.html
  • Understanding DNA variations www.ornl.gov/hgmis/publicat/hgn/v10n1/06snps.html
  • Explaining the human genome project www.nhgri.nih.gov/Policy_and_public_affairs/Communications/Publications/Maps_to_medicine/about/html
references1
REFERENCES

6. Angiogenesis www.bioportfolio.com/news/leaddiscovery_10.htm

7. Stem cells www.genome.gov/page.cfm?pageID=10000345

8. Gene clues and CVD www.the-aps.org/press_room?release2-19-02.htm

9. Use of stem cellls on mice www.seniors.gov/articles/0401/heartattack

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