肿瘤基因组学 肿瘤整合组学. 中南大学肿瘤研究所 向娟娟 ( [email protected] ) 2012 年 5 月 18 日. A turning point in cancer research: sequencing the human genome. Science. 1986 7;231(4742):1055-6.
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From genetics to genomics
Citric acid cycle
Networks in Cellular Systems
To date, cellular networks are most available for the super-model organisms (Davis, 2004) yeast, worm, fly, and plant. High-throughput interactome mapping
relies upon genome-scale resources such as ORFeome resources.
Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network
Science, 2001, 292:929
289WT GAL(+)/WT GAL(-)/ mRNA
Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targetsBMC Syst Biol. 2008 Jun 30;2:56.
Two human yeast two-hybrid data sets
Online interactome databases
Nonlinear stochastic model of dynamic protein-protein interactions
x [t + 1] = ax [t] +b1x1 [t] +b2x2 [t] + b3x3 [t] + c12x12 [t] + k + [t].
Global protein-protein interactions of apoptosis in cancerous and normal cells. (A) Apoptotic protein-protein interaction network in HeLa cells, showing 183 nodes and 552 edges. (B) Apoptotic protein-protein interaction network in normal primary lung fibroblasts, showing 175 nodes and 547 edges. Each interaction was calculated twice and only interactions with two '1' scores after AIC evaluation was considered 'true' interactions. All protein-protein interaction networks in this study were constructed with Osprey version 1.2.0.
Cancer-perturbed protein-protein interactions in the apoptosis network. (A) 'Gain-of-function' network, showing 140 nodes and 157 edges. (B) 'Loss-of-function' network, showing 126 nodes and 162 edges. Colors of nodes represent Gene Ontology annotations.
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