Infectious disease research at upstate medical university
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Infectious Disease Research at Upstate Medical University . SUNY REACH ID/EMERGING Pathogens Meeting June 20, 2013. Major Focus Areas. Pathogens: Viruses DNA viruses (HSV, VZV, CMV, EBV, KSHV, MHV-68) RNA viruses (Dengue, Pneumovirus , RSV) Malaria Models: Model of Sepsis in Pigs

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Infectious Disease Research at Upstate Medical University

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Infectious disease research at upstate medical university

Infectious Disease Research at Upstate Medical University

SUNY REACH ID/EMERGING Pathogens Meeting

June 20, 2013


Major focus areas

Major Focus Areas

Pathogens:

Viruses

  • DNA viruses (HSV, VZV, CMV, EBV, KSHV, MHV-68)

  • RNA viruses (Dengue, Pneumovirus, RSV)

    Malaria

    Models:

    Model of Sepsis in Pigs

    Humanized SCID mouse models

    Antigen presentation using Listeria


Dengue virus

Dengue virus

  • Epidemiology in Thailand and Ecuador (Endy, Polhemus, Stewart, and King)

  • Pathogenesis (Princiotta, Winslow, King and Endy)

  • Clinical trial for vaccine (Polhemus, Endy)


Pediatric infectious disease research team at upstate medical university

Pediatric Infectious Disease Research team at Upstate Medical University

Joseph Domachowske MD

ManikaSuryadevara MD

Cynthia Bonville MS


Research interests

Research Interests

  • Laboratory studies on the innate immune responses to respiratory viral infections

  • Translational studies in children with respiratory viral infections

  • Clinical vaccine trials in children


Laboratory studies on the innate immune responses to respiratory viral infections

Laboratory studies on the innate immune responses to respiratory viral infections

  • Models of severe viral infection using the pneumonia virus of mice and Sendai virus

    • Severe illness mirrors human infant infection with respiratory syncytial and parainfluenza viruses

  • Goals

    • Identify innate immune responses that are associated with illness severity

    • Develop and test compounds that target and attenuate this robust inflammatory response


Translational studies in children with respiratory viral infections

Translational studies in children with respiratory viral infections

  • Respiratory syncytial virus epidemiology

    • Longitudinal birth cohort study

  • Identification of upper respiratory tract biomarkers for infant RSV infection severity

    • Develop and test compounds that target and attenuate this robust inflammatory response

  • Documentation of the degree of neutrophil activation during infant RSV infection (ex vivo)


Clinical vaccine trials in children

Clinical vaccine trials in children

  • Vaccine perceptions of routine immunizations in families of resource poor children in CNY (with NYSOCHD and Salvation Army)

  • Global perceptions of vaccine safety and efficacy by providers of pediatric care in the U.S., Central America, Asia and Australia (with American Academy of Pediatrics, and [email protected] (GAVI, UNICEF, WHO)

  • Intranasal RSV vaccine (Medimmune)

  • Intranasal parainfluenza vaccine (MI)

  • Intranasal quadrivalent influenza vaccine (MI)

  • Inactivated quad influenza vaccine (GSK)


Herpesviruses

Herpesviruses

  • Longitudinal birth cohort based in Kenya

    • Primary EBV, KSHV and CMV infection in infants and impact of malaria on viral persistence (Rochford, Chan)

  • Virus-Cell interaction

    • Stat3 activation by KSHV (King)

    • Inhibition of monocyte apoptosis by CMV (Chan)

    • DNA replication of HSV (Hwang)


Humanized scid mouse model core

Humanized SCID Mouse Model Core

  • Interaction of varicella zoster virus (VZV) with human cells and tissues using skin and thymus that is implanted into SCID/beige mice. (Moffat)

  • Evaluation of anti-viral compounds (Moffat)

  • Evaluation of anti-malaria compounds (Rochford)


Host defense against intracellular pathogens

Host defense against Intracellular Pathogens

  • Ehrlichiamuris infection of mice and role of IgM memory B cells (Winslow)

  • TB (Winslow)


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