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Infectious Disease Research at Upstate Medical University . SUNY REACH ID/EMERGING Pathogens Meeting June 20, 2013. Major Focus Areas. Pathogens: Viruses DNA viruses (HSV, VZV, CMV, EBV, KSHV, MHV-68) RNA viruses (Dengue, Pneumovirus , RSV) Malaria Models: Model of Sepsis in Pigs

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Infectious Disease Research at Upstate Medical University

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Infectious Disease Research at Upstate Medical University

SUNY REACH ID/EMERGING Pathogens Meeting

June 20, 2013


Major Focus Areas

Pathogens:

Viruses

  • DNA viruses (HSV, VZV, CMV, EBV, KSHV, MHV-68)

  • RNA viruses (Dengue, Pneumovirus, RSV)

    Malaria

    Models:

    Model of Sepsis in Pigs

    Humanized SCID mouse models

    Antigen presentation using Listeria


Dengue virus

  • Epidemiology in Thailand and Ecuador (Endy, Polhemus, Stewart, and King)

  • Pathogenesis (Princiotta, Winslow, King and Endy)

  • Clinical trial for vaccine (Polhemus, Endy)


Pediatric Infectious Disease Research team at Upstate Medical University

Joseph Domachowske MD

ManikaSuryadevara MD

Cynthia Bonville MS


Research Interests

  • Laboratory studies on the innate immune responses to respiratory viral infections

  • Translational studies in children with respiratory viral infections

  • Clinical vaccine trials in children


Laboratory studies on the innate immune responses to respiratory viral infections

  • Models of severe viral infection using the pneumonia virus of mice and Sendai virus

    • Severe illness mirrors human infant infection with respiratory syncytial and parainfluenza viruses

  • Goals

    • Identify innate immune responses that are associated with illness severity

    • Develop and test compounds that target and attenuate this robust inflammatory response


Translational studies in children with respiratory viral infections

  • Respiratory syncytial virus epidemiology

    • Longitudinal birth cohort study

  • Identification of upper respiratory tract biomarkers for infant RSV infection severity

    • Develop and test compounds that target and attenuate this robust inflammatory response

  • Documentation of the degree of neutrophil activation during infant RSV infection (ex vivo)


Clinical vaccine trials in children

  • Vaccine perceptions of routine immunizations in families of resource poor children in CNY (with NYSOCHD and Salvation Army)

  • Global perceptions of vaccine safety and efficacy by providers of pediatric care in the U.S., Central America, Asia and Australia (with American Academy of Pediatrics, and Shot@Life (GAVI, UNICEF, WHO)

  • Intranasal RSV vaccine (Medimmune)

  • Intranasal parainfluenza vaccine (MI)

  • Intranasal quadrivalent influenza vaccine (MI)

  • Inactivated quad influenza vaccine (GSK)


Herpesviruses

  • Longitudinal birth cohort based in Kenya

    • Primary EBV, KSHV and CMV infection in infants and impact of malaria on viral persistence (Rochford, Chan)

  • Virus-Cell interaction

    • Stat3 activation by KSHV (King)

    • Inhibition of monocyte apoptosis by CMV (Chan)

    • DNA replication of HSV (Hwang)


Humanized SCID Mouse Model Core

  • Interaction of varicella zoster virus (VZV) with human cells and tissues using skin and thymus that is implanted into SCID/beige mice. (Moffat)

  • Evaluation of anti-viral compounds (Moffat)

  • Evaluation of anti-malaria compounds (Rochford)


Host defense against Intracellular Pathogens

  • Ehrlichiamuris infection of mice and role of IgM memory B cells (Winslow)

  • TB (Winslow)


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