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NSAIDs????. 2. ???????????(15). ?????????????. ?NSAIDs????????????????????????????????(NSAIDs)??????????????????????????????????????????????????????????????????????????????????????????????????(???????????)???????????????????????????????????????????????????????????????????????????????????????24 ??

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15

PMS

PMS12

NSAIDs


NSAIDs

NSAIDs24

100 10%NSAID

NSAIDs COX COX-1

NSAIDs


NSAIDs

NSAIDs


NSAIDs


  • NSAIDs

NSAIDs


NSAIDs


NSAIDs

Asthmatic attack due to NSAIDs (non-steroidal anti-inflammatorydrugs)

24

NSAIDs


NSAIDs 1

NSAIDs 1 24 NSAIDs

cysLTs LTE4

NSAIDs


NSAIDs

NSAIDs

COX-1 SAIDs

NSAIDs

NSAIDs


PG COX-1 COX-1 PGE2 cysLTs COX-SAIDs COX-1 NSAIDs NSAIDs NSAIDs COX-1 NSAIDs

10 10 30 50

2004 3,283 10 2.62.6

NSAIDs


NSAIDs


20 50 6 NSAIDs NSAIDs

NSAIDs

COX-1 NSAIDs

NSAIDs 12

NSAIDs


NSAIDs

2

NSAIDs

NSAIDs NSAIDs

NSAIDs

COX-1 NSAIDs /

NSAIDs


NSAIDs

NSAIDs

NSAIDs


30

3040 23

NSAIDs


100 mg

NSAIDs

NSAIDs


NSAIDs

NSAIDs

NSAIDs 2030COX

NSAIDs

X

NSAIDs

NSAIDs NSAIDs NSAIDs

NSAIDs


NSAIDs

NSAIDs

NSAIDs

NSAIDs NSAIDs

a)

b)

c)

NSAIDs

NSAIDs


MedDRA

Asthma

Atopic asthma

Athematic attack atopic

Allergic asthma

Extrinsic asthma

Cough variant asthma

Cold induced asthma

Bronchitic asthma

Asthma bronchial

Intrinsic asthma

Chronic obstructive asthma (with

obstructive pulmonary disease)

Asthma chronic

Drug-induced asthma

Asthma

Asthma, unspecified

PT (Preferred Term)

LLT (Lowest Level Term)

NSAIDs


MedDRA

AsthmaNOS

Asthmatic

Bronchitis asthmatic

Asthma aggravated

Asthmatic attack

Asthmatic attack induced

Asthma-like condition

Analgesic asthma syndrome

Asthma aspirin-sensitive

Aspirin asthma

Widal syndrome

Samter's syndrome

Analgesic asthma syndrome

NOS

PT (Preferred Term)

LLT (Lowest Level Term)

NSAIDs


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