Medical parasitology
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MEDICAL PARASITOLOGY

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Medical parasitology

MEDICAL PARASITOLOGY

Department of Microbiology and Parasitology, SSMU


Medical parasitology

医学寄生虫学(Medical parasitology)Medical parasitology,the study of animality pathogen动物性病原体 harming human health, is one of basic science of preventive medicine and clinical medicine. It studies the pathogenic parasites寄生虫 and their relationships to the hosts宿主 and environment.it consists of medical protozoology医学原虫学, medical helminthology医学蠕虫学 and medical entomology医学节肢动物学.


Medical parasitology

A large mass of Ascaris lumbricoides that was passed from the intestinal tract.  The ruler at the bottom of the image is 4 cm (about 1.5 inches) in length.


Medical parasitology

S.japonicum:


Medical parasitology

WHO重点防治的寄生虫病种类

malaria (疟疾)

schistosomiasis (血吸虫病)

filariasis (丝虫病)

leishmaniasis (利什曼病)

trypanosomiasis (锥虫病)


Medical parasitology

Malaria<30万

Schistosomiasis约70万(03年100万)

Filariasis 近期被消灭

Leishmaniasis300~400例/年

Hookworm disease2亿多(3930万)

流行概况(国内)


Medical parasitology

我国寄生虫病流行情况

1.约5亿人感染土源性寄生虫(80%),下降了约60%(与全国第一次普查)

2.食源性寄生虫病上升、并向城镇扩散,上升了75%(与第一次普查)

3.囊虫病在中、西、北部地区流行

4.弓形虫病呈扩大传播趋势

5.包虫病造成畜牧业巨大经济损失


Parasitism

一、寄生现象(Parasitism)

(一)共生 (symbiosis)

Any organism that spends a portion or all of its life intimately associated with another living organism of a different species is known as symbiont 共生者, and the relationship is designated as symbiosis.

根据两种生物间的利害关系,大致可分为共栖、互利共生和寄生三种现象。


1 commensalism

1.共栖(commensalism)

Commensalism共栖现象denotes an association that is beneficial to one partner and the neither benefited nor damaged to the other.

(人 ——结肠内阿米巴)


2 mutualism

2.互利共生(mutualism)

Mutualism互利共生 is seen when such associations are beneficial to both organisms.

(白蚁 ——鞭毛原虫)


3 parasitism

3.寄生(parasitism)

Parasitism寄生现象is a symbiotic relationship in which one animal, the host宿主, is to degree injured through the activities of the other, the parasite寄生虫.Parasite usually is the smaller of the two organisms.

(蛔虫 ——人)


Parasite

Parasite

  • Obligate parasite

    • An organism that cannot survive in any other manner is called an obligate parasite(专性寄生虫).

  • Facultative parasite

    • Facultative parasite(兼性寄生虫) is an organism that may exist in a free-living state or as a commensal and that, if opportunity presents itself, may become parasitic.

    • It is implicit in this term that the organism does not of necessity have to be a parasite at any stage of its existence.


Medical parasitology

  • Temporary parasite

    • Temporary parasite are obligatory parasites at one or more stages of their life cycles but free living at others.

  • Endoparasites and ectoparasites

    • Parasites living within the host may be described as endoparasites, whereas those that are found on the surface of the body are called ectoparasites.


Medical parasitology

opportunistic parasite:

(机会致病性寄生虫)在宿主免疫功能正常时处于非致病的隐性感染状态,当宿主免疫功能受损时,可出现异常增殖和致病力增强使人致病的寄生虫。(弓形虫)


Adaptations to parasitism

(二)Adaptations to Parasitism(寄生虫对寄生生活的适应)

  • Morphologic adaptations

    • Apicomplexa and Microspora protozoa have no locomotor organelles.

    • A digestive tract, is reduced in the trematodes and is absent in the cestodes.

    • The reproductive system is very highly developed in the trematodes and cestodes.

    • Specialized attachment organs have been developed by the flatworms.

    • Many of parasites are much larger than their free-living relatives.


Medical parasitology

  • Biochemical changes

  • Develop specialized mechanisms for effecting entrance into the body or tissue.

  • Successfully overcome the immune response of the host

    • Locate in relatively protected sites

    • Changes in the parasite surface antigenic structure

    • Modify the host immune response by products of parasite metabolism

  • Increase reproductive capacity


Medical parasitology

(三)host

  • Definitive host(终宿主)

    • The host in which sexual reproduction occurs is called the definitive host.

  • Intermediate host(中间宿主)

    • The specie in which larval develop is called intermediated host.


Medical parasitology

  • Reservoir host(保虫宿主/储蓄宿主)

    • Reservoir host is an animal which harbors parasites in nature and acts as a source of infection.

  • Paratenic host(转续宿主)

    • A host which acts as a transporting agent for the parasite and in which the parasite does not undergo any development is called paratenic host.


Medical parasitology

二、 life cycle(生活史 )

The parasitic life cycle is the obligatory of parasites for their growth, development and multiplication that may be accomplished in their host (or hosts) or environment.

  • 直接型生活史:不需要中间宿主

  • 间接型生活史:需要中间宿主


Medical parasitology

Stage in man

Migration and

localization

(pathogenicity

treatment and diagnosis) Stool

Urine Mouth Bronchial

Contact Secretion

Vector Vector

(Pathogenicity (diagnosis)

and Prophylaxis)

(Epidemiology and Prophylaxis)

Infective stage

Stage left man

Stage in environment (vector)


Medical parasitology

  • Infective stage(感染期)

    • A stage of parasite which can enter the human body and develop continuously there.


Medical parasitology

  • Carrier

    • Carrier is a person who carries a certain parasite without displaying any sign or symptom of diseases acting the source of infection


Effects of the parasite on the host

Effects of the Parasite on the Host

  • Parasite infection and parasitic disease.

  • Overt symptoms of infection may depend on the number of worms present, the nutritional status of the host, or both.

  • Injury to the host may be brought about in many ways.

    • Interference with the vital processes of the host through the action of secretions, excretions, or other products of the parasite.

    • Invasion and destruction of host tissue.

    • Deprive essential substances of the host.


Effects of the host on the parasite

Effects of the Host on the parasite

  • The genetic constitution of the host.

    • Absence of the Duffy blood ~ P. vivax

    • Sickle cell trait ~ P. falciparum

  • The diet or nutritional status of the host.

    • A high-protein diet ~ intestinal protozoa

    • Carbohydrate in the diet ~ tapeworms

    • Nutritional status of the host


Medical parasitology

  • Innate immunity

  • Acquired immunity

    • Can be demonstrated in many parasitic disease

    • Absolute immunity to reinfection is rarely following following protozoal infections and probably never with helminth infection. Just resists to hyperinfection.

    • No long-lasting immunity maintains while the parasites are still in the body.

    • Premuniton in malariaConcomitant immunityin schistosomiasis


Epidemiology

Epidemiology

  • Source of infection

    patient, carrier and reservoir host

  • Transmission route

    water, food, soil, air, insect vector and so on

  • Susceptible population

    People except those will special background are all susceptible to parasitic infection.


Epidemiological factors

Epidemiological factors

  • Natural factors

    • Climate, geography, species of parasites and vectors

  • Socio-economic factors

    • Social system, economic situation, life condition and mode, hygienic condition

  • Individual factors

    • Sex, age, profession, ethnic group


Control

Control

  • Destruction of source of infection

  • Interruption of transmission

  • Protection of susceptible population


Prevalence of parasitic infections

Prevalence of Parasitic Infections

Malaria

  • Infected, 400 to 490 million

  • Annual deaths, 2.2 to 2.5 million


Medical parasitology

Schistosomiasis

  • Infected, 150 million

  • Annual deaths, 500,000 to 1 million


Medical parasitology

Lymphatic filariasis

  • 128 million infected


Medical parasitology

Leishmaniasis

  • Infected, 1.2 million


Medical parasitology

  • Hookworm

    • 1.3 billion infected

  • Amebiasis

    • Infected, 1% world population

    • Annual deaths, 40,000 to 110,000

  • Ascariasis

    • 1.3 billion infected

    • Annual deaths (intestinal obstruction), 1550


Important groups of human parasites

Helminthes

Nematode

Trematode

Cestode

Important Groups of Human Parasites

  • Protozoa

  • Amoeba

  • Flagellate

  • Sporidium

  • Ciliate

  • Arthropoda

  • Mosquito

  • Fly

  • Tick

  • Mite

  • Bug

  • Flea

  • Lice


Nematode

The intestinal nematodes

Ascaris

Hook worm

Pinworm

Whip worm

The blood- and tissue dwelling nematodes

The filaria

Trichinella

Nematode


Learning method

Learning method

Infectivename Pathogenesis

stageroutePrevention

mode

Life cyclePathogenicname Pathogenesis

stagelocalizationTreatment

migration Diagnosis

Diagnosticstage-morphologyDiagnosis

stagemethods

stage outside name Epidemiology

(vector, other host) name Prevention


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