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AIM

ApoC-III variants contribute to the variability of cholesterol and triglyceride levels in HIV-infected children under HAART regimen. Andrea Mangano 1,2,3 , C. Rocco 1 , M.E. Tonelotto 1 , P. Aulicino 1 , D. Mecikovsky 1 , N. Escobal 1 , R. Bologna 1,3 , L. Sen 1,2,3 .

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  1. ApoC-III variants contribute to the variability of cholesterol and triglyceride levels in HIV-infected children under HAART regimen Andrea Mangano1,2,3, C. Rocco1, M.E. Tonelotto1, P. Aulicino1, D. Mecikovsky1, N. Escobal1, R. Bologna1,3, L. Sen1,2,3. 1Hospital Nacional de Pediatría “J. P. Garrahan”, 2Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. 3Fogarty AIDS International Training and Research Program

  2. AIM To evaluate the impact of 3’UTR 3238C/G apoC-III variant on total cholesterol and TGs levels during HAART in HIV-infected children Studied subjects I) 82 HIV-infected children during a two-year period (2005-2006), with a median age of 140 mo (IQR: 122-160). All the children received HAART therapy with a median of 78 mo ( IQR: 67-83). II) 100 randomly collected blood donors were included to estimate genetic frequencies of the SNP in general population

  3. RESULTS

  4. * Percentages correspond to: (patients with ≥1 abnormal high determination)/(patients with ≥2 determinations) A higher proportion of abnormal high TGs and cholesterol levels was observed among homozygous CC

  5. Odds ratios to abnormal TGs levels adjusted to Mixed-Effects logistic Model CG genotype showed a lower proportion of abnormal high TGs levels independent of time on HAART

  6. Odds ratios to abnormal Cholesterol levels adjusted to Mixed-Effects logistic Model The model suggests that for short follow-up studies, the effect observed for the genotype on cholesterol levels would depend greatly on the cohort experience on HAART. A increasing risk of abnormal high cholesterol was observed for the CC genotype

  7. CONCLUSIONS • Heterozygotes 3238 C/G had fewer events of abnormal high cholesterol, with a more prominent effect when HAART was received for long periods. • Heterozygotes 3238 C/G also showed fewer events of abnormal high triglycerides, independently of time on HAART. Our results suggest a protective effect of the 3'URT 3238C/G genotype of ApoC-III on the development of PI- related dyslipemia in HIV-infected children

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