Nanomaterial drug delivery
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Nanomaterial Drug Delivery. Group 5: Daniel Ehlers Daniel Barnes Ann-Marie Scarborough Nguyen Lam.

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Nanomaterial drug delivery

Nanomaterial Drug Delivery

Group 5:

Daniel Ehlers

Daniel Barnes

Ann-Marie Scarborough

Nguyen Lam


Nanomaterials For Drug Delivery

Interactive presentation

Interactive Presentation

  • To view an interactive version of this presentation, visit the link below (recommended):


Nanomaterial drug delivery

Nanomaterials are the future of drug delivery

Drugs are able to reach their site of action more effectively

Nanomaterial drug delivery

Bodily system barriers are able to be broken with nanocarriers

Advanced materials can target various cells, such as cancer cells.

Nanomaterial drug delivery

Drugs with different molecular shapes and chemical properties can be synthesized

Different properties results in greater possibilities

Background information

Background Information

  • All drugs face several transport barriers

    • Plasma membrane

    • The acidic environment of endolysosomes

    • Nuclear membrane

    • Multiple drug resistance mechanism

      from their site of introduction to their molecular site of action.

Background information1

Background Information



High-resolution image of detonation nanodiamonds

1. Very small size

2.High surface-to-volume ratio

3. One or more therapeutic drugs can be attached to



4.Attach to specific target cells and organs with selected binding agents

5.Helps to avoid the fluctuations of drug (by using time-release)

Polymers and cancer cells

Polymers and Cancer Cells

  • Other polymers allow for easy binding to tumor sites

  • At the correct pH and/or [Cl-] of a tumor site, the drug can be released

  • Certain polymers allow for delivery past protective DNA barriers in a tumor cell

Cylindrical miccles

Cylindrical Miccles

  • Initially block polymers

  • Hydrophillic end – causes them to form miccle shape with water

  • Hydrophobic end – Keeps them from being easily bound/absorbed to other things

  • Benefits:

    • Prolonged circulation

    • Reduction of off-target toxicity (less side effects)

    • Can be formed using existing drugs

Pegylation of drugs

PEGylation of Drugs

  • Adding PEG (Polyethylene glycol) polymer to existing drug molecular structure

  • Benefits:

    • Increases drug half life

    • Increases drug solubility at site of action

    • Increases drug stability

    • Slows down drug metabolism through kidneys, etc.

Ideal sirna cancer drug

Ideal siRNA Cancer Drug

  • siRNA – Small Interfering RNA can be inserted into a tumor cell to cause it to malfunction

  • Problem: Needs to be delivered to tumor site and not to healthy cells

  • In figure, nanomaterial (green) is attached to siRNA drug (purple ring)

Ideal sirna cancer drug1

Ideal siRNA Cancer Drug

  • Nanomaterial is PEGylated:

    • Increases drug half life

    • Increases drug solubility at site of action

    • Decreases interaction outside target side (and therefore side effects)

    • Increases drug stability

    • Slows down drug metabolism through kidneys, etc.

Ideal sirna cancer drug2

Ideal siRNA Cancer Drug

  • Nanomaterial searches for biological signals of a cancer cell

    • Certain peptides have this ability

  • Nanomaterial is engineered to bind to the unique receptors on the cancer cell

Ideal sirna cancer drug3

Ideal siRNA Cancer Drug

  • Another problem: Overcome defenses in cytoplasm of cancer cell

  • Nanomaterial overcomes defenses and rapidly delivers siRNA drug into cell

  • siRNA modifies the cancer cell DNA and causes it to die

Specific cancer drug design carbon nanotubes

Specific Cancer Drug Design: Carbon Nanotubes

  • Antibodies are designed that will fight cancer cells

  • Carbon Nanotube carriers have molecular strands that contain the antibodies and a link system to cancer cells

  • Recognize cancer cells by pH, biological markers

Specific cancer drug design carbon nanotubes1

Specific Cancer Drug Design: Carbon Nanotubes

  • Carbon Nanotubes can be PEGedand attached with antibodies to bring it specifically to a cancer cell

  • The drugs inside the nanotube can be released in the presence RF frequencies

  • Metal nanotubes also heat in presence of RF waves, and “burn up” cancer cells

Specific cancer drug design nanodiamonds

Specific Cancer Drug Design: Nanodiamonds

  • Drug can be placed in nanodiamonds

  • Nanodiamonds contain receptors that allow them only to bind and react with tumor cells

  • Nanodiamonds release drug into tumor cell and result in highly effective treatment

Assessment of work

Assessment of Work

  • The use of Nano-Diamonds and their effects on the PH increase solubility in the solution for several types of deliveries by making the pH closer to that of the natural body levels

  • Table 1

  • Plotted n value of the release of RB from carbon nanomaterials at pH 7.4 and pH 4.5.

  • n value at pH 7.4 n value at pH 4.5 Drug release mode

  • CB–RB 0.39 0.32 Fickian diffusion

  • CNT–RB 0.42 0.64 Fickian diffusion at pH 7.4,

  • anomalous transport at pH 4.5

  • f-CNT–RB 0.5 0.64 Anomalous transport

  • GO–RB 1 0.63 Case II transport at pH7.4,

  • anomalous transport at pH 4.5

  • Zhang and Olin Pg. 1251

Assessment of work1

Assessment of Work

  • In addition, they allow for a controlled time release of the drug for consistant delivery

  • Zhang and Olin pgl. 1250

Time (min)

Assessment of work2

Assessment of Work

  • Allows better ability to Penetrate the Plasma wall of the cells

  • Can release on correct rNA code recognition for needed antigen.



  • The use of Nano-Diamonds allows the Pharmicutical Industry to be much more presice in drug delivery due to

    • pH Control

    • Time Release Control

    • rNA Release Control



  • It also allows a larger range of effective drugs to be administered from

    • Size Control

    • pH Control

Further research suggested

Further Research Suggested

  • Hazards/toxicity of particles

  • Cancer research



  • Nanomaterials for Drug Delivery. Jeffrey A. Hubbell and AshutoshChilkoti. Science 20 July 2012: 337 (6092), 303-305. [DOI:10.1126/science.1219657]

  • Nanodiamonds as novel nanomaterials for biomedical applications: drug delivery and imaging systems. Badea, Ildiko and Kaur, Randeep. International Journal of Nanomedice. 8. Jan 2013. Web. 2 April 2013

  • Computational design of a CNT carrier for a high affinity bispecificanti-HER2 antibody based on trastuzumaband pertuzumabFabs. Salazar-Salinas Karim, Kubli-Garfias, Carlos, and Seminario, Jorge M. Springer-Verlag.

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