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Case 4

Case 4. F, 70 ys, lower leg Erythematous patch Clinical suspicious: pemphigoid? Patient followed by Department of Oncology. Punch biopsy. CD20. CD3. CD3. CD79a. CD5. CD23. CD43. Mib-1. Further clinical information. History of B-CLL FINAL DIAGNOSIS

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Case 4

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  1. Case 4 F, 70 ys, lower leg Erythematous patch Clinical suspicious: pemphigoid? Patient followed by Department of Oncology

  2. Punchbiopsy

  3. CD20

  4. CD3

  5. CD3

  6. CD79a

  7. CD5

  8. CD23

  9. CD43

  10. Mib-1

  11. Further clinical information • History of B-CLL FINAL DIAGNOSIS Cutaneous localization of B-CLL CD20+; CD79a+; CD5+; CD23+; CD43+; CD3-.

  12. Follow-up: spontaneous resolution of the lesion(Kazakov D et al. Dermatology 2003; 207: 111-115) • H&E: monomorphous lymphocytes, small size but with hyperchromatic nuclei • Immunohistochemistry: large panel r/o Mantle Cell Lymphoma (cyclin D1-; low Mib-1) • Clinical information: not given, at least directly!

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