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Hans VAN REMOORTEL Turkish Thoracic Society Congress April 3-7, 2013 Belek - Antalya PowerPoint PPT Presentation


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The relationship between symptom experience and the level of daily physical activity in patients with COPD. Hans VAN REMOORTEL Turkish Thoracic Society Congress April 3-7, 2013 Belek - Antalya. www.proactivecopd.com.

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Hans VAN REMOORTEL Turkish Thoracic Society Congress April 3-7, 2013 Belek - Antalya

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Hans van remoortel turkish thoracic society congress april 3 7 2013 belek antalya

The relationshipbetweensymptomexperience and the level of dailyphysicalactivityin patientswith COPD

  • Hans VAN REMOORTEL

  • TurkishThoracic Society Congress

  • April 3-7, 2013

  • Belek - Antalya


Hans van remoortel turkish thoracic society congress april 3 7 2013 belek antalya

www.proactivecopd.com

The PROactive project is funded by the Innovative Medicines Initiative Joint Undertaking (IMI JU) # 115011; and matching funds at each academic institution

Academic partners

Patient / Scientific

organizations

EFPIA members

Small Medium Enterprise


Rationale

Rationale

  • Functional performance (Kocks PCRJ 2011)

  • = activitiespeopleactually do

    • Reduces risk hospitalizationduetoexacerbation(Garcia-AymerichThorax 2003)

    • Relatedtoquality of life(Arne IJCOPD 2011)

    • Predictor all-causemortality(Garcia-rioChest 2012)

1.0

Q4

Q3

0.8

Probability of survival

0.6

Q2

0.4

Q1

80

60

0

20

40

Time (months)


Rationale1

Rationale

  • Measurement(Kocks PCRJ 2011)


Rationale2

Rationale

Field assessment: Activity monitors (accelerometry (+ other sensors))

Rabinovich et al.; European Respiratory Journal; 2013

Van Remoortel et al.; Plos One; 2012


Rationale3

Rationale

Patient report: Clinical COPD Questionnaire (CCQ) functional status domain

Adapted from T. van der Molen, Department of General Practice, University Medical Center, Groningen, The Netherlands


Rationale4

Rationale

Objectivemeasurements

CCQ functional status domain

6

5

4

25000

20000

3

15000

CCQ functional status domain

Steps.day-1

2

10000

5000

1

IV

III

C

I

II

0

I

III

IV

II

Shrikrishna ERJ 2012

Liu SWJ 2012

GOLD stage

GOLD stage


Rationale5

Rationale

Objectivemeasurements

CCQ functional status domain

1.0

1.0

Q4

<1

Q3

1 & <2

0.8

0.8

2 & <3

Probability of survival

Probability of survival

Q2

0.6

0.6

3

0.4

0.4

Q1

80

60

0

60

20

40

0

20

40

Time (months)

Time (months)

Garcia-rio, Chest, 2012

Sundh, IJCOPD, 2012


Methods

Methods

  • Aim= Identifythe relationbetweenfunctional performance measuredby PRO and physicalactivity monitoring at the individualpatientlevel

  • Inclusion

    • + 40y

    • FEV1/FVC < 70%

    • +10 pack years

  • Exclusion

    • Impairment of normalmovementpatternunrelatedtorespiratorydisease

    • Otherrespiratorydisease


Methods1

Methods

  • Design

Spirometry

6MWD

mMRC

CAT

CCQ

CRQ-SAS

mMRC

CAT

CCQ

CRQ-SAS

mMRC

CAT

CCQ

CRQ-SAS

mMRC

CAT

CCQ

CRQ-SAS

V4

V1

V2

V3

14 days

14 days

14 days

PA monitoring

PA monitoring


Results

Results

  • Baseline characteristics


Results1

Results

  • Physicalactivity monitoring

  • PatientReportedOutcome


Results2

Results

  • Univariatecorrelations STEPS (amount)

r= -0.51

r= -0.33

r= -0.50

r= -0.45


Results3

Results

  • Univariatecorrelations INTENSITY DURING WALKING

r= -0.49

r= -0.31

r= -0.49

r= -0.45


Conclusion

Conclusion

  • Functional performance measuredwith a PRO is modestlyrelated to the amount and intensity of PA.

  • Information obtainedwith a PRO does not provide aninsight in the physicalactivity level of patientswith COPD and canthereforenotbeused as a surrogateforobjective PA measurement.

  • PROactive tool = capturingphysicalactivitybyanobjectiveassessment (activitymonitoring) ANDsymptomexperience of the patients (PRO).


Hans van remoortel turkish thoracic society congress april 3 7 2013 belek antalya

Prof. Dr. M. Decramer

Prof. Dr. W. Janssens

Prof. Dr. T. Troosters

Prof. Dr. R. Gosselink


Hans van remoortel turkish thoracic society congress april 3 7 2013 belek antalya

Thankyouforyourattention!

[email protected]


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