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Application of Asilomar Guidelines to Self-Replicating Machines. 5th Terasem Workshop on Geoethical Nanotechnology 2009 July 20th Terasem Island, Second Life. Presentation Structure. Reconciling conflicts regarding self-replicating nanotechnology Apprehensions about gray goo

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Application of asilomar guidelines to self replicating machines

Application of Asilomar Guidelines to Self-Replicating Machines

5th Terasem Workshop

on Geoethical Nanotechnology

2009 July 20th

Terasem Island, Second Life

[email protected]


Presentation structure
Presentation Structure Machines

  • Reconciling conflicts regarding self-replicating nanotechnology

  • Apprehensions about gray goo

  • Scientific ambitions in remaking life

  • Applying practical biotechnology guidelines to artificial self-replication

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The self replicating machines conflict
The Self-Replicating Machines Conflict Machines

  • We need self-replicating machines for enhanced survival

  • We are afraid that such machines will jeopardize our survival

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Self replicating nanotech is most useful to extended life
Self-Replicating Nanotech Is Most Useful to Extended Life Machines

Human

Body

Creates

50x106

Cells

Per

Second

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Since nature needed it nanotechnologists will probably need it
Since Nature Needed It, Nanotechnologists Will Probably Need it

If Nature Couldn’t Do Without Self-Replication, It Is Likely That Our Efforts to Extend Nature Will Not Succeed Without Self-Replicating Technology

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Of course nature also gave us smallpox and hiv
Of Course Nature Also Gave Us Smallpox and HIV it

500 Million People Killed By Smallpox

HIV Killes 250,000

People MONTHLY

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Presentation structure1
Presentation Structure it

  • Reconciling conflicts regarding self-replicating nanotechnology

  • Apprehensions about gray goo

  • Scientific ambitions in remaking life

  • Applying practical biotechnology guidelines to artificial self-replication

[email protected]


Crichton imagined self replicating nanobots would swarm against us
Crichton Imagined Self-Replicating Nanobots Would Swarm Against Us

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Self replication scares us
Self-Replication Scares Us Against Us

“However, a determined and sophisticated group of terrorists or "non state entities" could potentially, with considerable difficulty, specifically engineer systems to become autonomous replicators able to proliferate in the natural environment, either as a nuisance, a specifically targeted weapon, or in the worst case, a weapon of mass destruction.”

foresight.org/guidelines/current.html#Replicators 2006

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Presentation structure2
Presentation Structure Against Us

  • Reconciling conflicts regarding self-replicating nanotechnology

  • Apprehensions about gray goo

  • Scientific ambitions in remaking life

  • Applying practical biotechnology guidelines to artificial self-replication

[email protected]


Uploaded minds will want nanotech bodies
Uploaded Minds Will Want Nanotech Bodies Against Us

HEAVEN VIRUS

MIND CHILDREN

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Vitrified bodies may need self replicating nanotech for revival
Vitrified Bodies May Need Self-Replicating Nanotech for Revival

MOLECULAR ASSEMBLY

v. BOLUS INJECTION(S)

When ALCOR RevivesIts Patients…

Can Trillions of Injected Nanobots Handle It, Or Will They Need Replicate?

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Space colonists may need self replicating nanotech for world building
Space Colonists May Need Self-Replicating Nanotech for World-Building

CIVILIZATION-READY

BUILD & THEY’LL COME

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Humanity needs self replicating nanotech for galactic surveillance
Humanity Needs Self-Replicating Nanotech for Galactic Surveillance

BUILD A COPY. REPEAT.

FIND A GOOD PLANET

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Presentation structure3
Presentation Structure Surveillance

  • Reconciling conflicts regarding self-replicating nanotechnology

  • Apprehensions about gray goo

  • Scientific ambitions in remaking life

  • Applying practical biotechnology guidelines to artificial self-replication

[email protected]


Very similar situation with recombinant biotechnology
Very Similar Situation with Recombinant Biotechnology Surveillance

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Huge increase in practicality by permitting self replication
Huge Increase in Practicality By Permitting Self-Replication Surveillance

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Apply asilomar rules of recombinant dna to nano
Apply ASILOMAR Rules of Recombinant DNA to Nano? Surveillance

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The asilomar guidelines
The Asilomar Guidelines Surveillance

  • containment essential & must match the risk

  • use of biological barriers to limit the spread e.g. host-specific & nonsurvivable

  • physical containment,

  • good microbiological practices & training

  • no cloning of recombinant DNAs derived from highly pathogenic organisms, containing toxin genes, or making biohazards that could not be contained

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Matching the risk
Matching the Risk Surveillance

rDNA HGH

  • Minimal and low risk

    • minimal if biohazards could be accurately assessed and were expected to be minimal.

    • Low risk if novel biotypes but not

      • change ecological behavior of the recipient species,

      • increase significantly its pathogenicity or

      • prevent treatments of any resulting infections.

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Minimal risk containment
Minimal Risk Containment Surveillance

  • Prokaryotes, bacteriophages and other plasmids, experiments could be performed in minimal risk containment facilities when the construction of recombinant DNA molecules and their propagation involved prokaryotic agents that were known to exchange genetic information naturally

  • Additionally, purified DNA from any source that performed known functions and was judged to be non-toxic could be cloned with available vectors in low risk containment facilities

Bacteriophage T4 infecting an e. coli host

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Moderate and high risk
Moderate and High Risk Surveillance

  • The moderate risk level of containment if significant potential for pathogenicity or ecological disruption.

  • High-risk containment if a serious biohazard to laboratory personnel or to the public.

  • DNAs of species that result in new metabolic pathways in species, use moderate or high-risk containment

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Asilomar guidance relevant to bio nano
Asilomar Guidance Relevant to Bio-Nano Surveillance

Nano-neuron

Unless the organism made a dangerous product, recombinant DNAs from cold-blooded vertebrates and all other lower eukaryotes could be constructed and propagated with the safest vector-host system available in low risk containment facilities.

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Self replicating nanotech are like asilomar low risk examples
Self-Replicating Nanotech Are Like Asilomar Low-Risk Examples

  • A mech analog of a rDNA

  • Not banned if not toxic

  • “Low-Risk” because novel biotype but doesn’t change ecology or  pathogenicity

  • Changing the nature of an uninhabited world doesn’t count as changing ecology

  • Not “Minimum Risk” because unnatural replication method

  • Not “Moderate” or “High” Risk since not high potential for pathogenicity, ecological harm or biohazard

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So what rules needed for self replicating nanobots
So, What Rules Needed for Self-Replicating Nanobots? Examples

  • Use of biological barriers to limit harm

  • Biological nanobots should fail-safe disable in atmosphere

  • Robotic nanobots should fail-safe disable in biochemistry

  • Planetary nanobots should fail-safe disable by - gravitaxis

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Autonomous v non autonomous self replication
Autonomous v. ExamplesNon-Autonomous Self-Replication

  • Non-Autonomous Self-Replication Is Feasible When Real-Time Human Control Exists

  • Autonomous Self-Replication Is Needed for Galactic Missions

  • Line Between Non-Autonomous and Autonomous Very Blurry When AI Agents Assist Humans In Effecting Control

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Dr o neill less than 500k years to colonize galaxy
Dr. O’Neill: Less Than Examples500K Years to Colonize Galaxy

My concept of such a probe is that it would go to another star system, neighboring the original one. It would use the asteroidal material available there. In a period of a few years, it would replicate itself. It would then leave one of itself at that star and move off to the next star and so on. As it went, it would establish two-way communication, point-to-point, not a broadcast at all, but from one of these replicator probes to the next. You can work out the numbers, and it turns out that by any reasonable standards such a probe system could cover essentially every star in the galaxy within a time of no more than half a million years.

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O neill galactic colonization
O’Neill Galactic Colonization Examples

  • Clearly Requires Autonomous Self-Replication of Machines

  • Why Not Include Uploaded Minds In Each Probe, Including Instructions for Creating Nano or Nano-Bio Bodies?

  • Ergo, Galactic HUMAN Colonization Requires Autonomous Self-Replication

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Asilomar will need to be segmented for galactic colonization
Asilomar Will Need to be Segmented for Galactic Colonization Examples

  • Planetary Replicator Probes Need to be Able to Blast Off the Planet

  • Robotic Nanobots Need to Co-Exist in Nano-Bio Bodies for Downloaded Minds of Colonists

  • Biological Nanobots May Need to Survive ex vivo for the Ecology

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Bottom line
Bottom Line Examples

  • Asilomar is Common Sense:

    • Self-Replicating Objects Should be Contained from Causing Harm While Free to Do Good

    • Each Case By Its Specific Facts

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Going forward
Going Forward Examples

  • Self-Replicating Nanotech Covered by Asilomar Regime

    • Same Issues,

    • New Substrate

  • Asilomar Regime Must Be Segmented for Galactic Colonization

  • We Can Extend Our Lives with Nanotech Bodies, Nanomedicine & World-Building

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