Pyruvate oxidation pyruvate dehydrogenase complex
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Pyruvate Oxidation Pyruvate dehydrogenase complex. Aerobic Fate of Pyruvate: Overview. Mitochondria: Site of Oxidations. Pyruvate Oxidation to Acetyl-CoA. Pyruvate Dehydrogenase Complex. Complex enzyme 60 polypeptides of 3 kinds In mitocondrion matrix Regulated Inhibited by NADH and GTP

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Pyruvate oxidation pyruvate dehydrogenase complex

Pyruvate OxidationPyruvate dehydrogenase complex





Pyruvate dehydrogenase complex
Pyruvate Dehydrogenase Complex

  • Complex enzyme

    • 60 polypeptides of 3 kinds

  • In mitocondrion matrix

  • Regulated

    • Inhibited by NADH and GTP

    • Stimulated by insulin


Pyruvate dehydrogenase complex1
Pyruvate Dehydrogenase Complex

  • Three enzymes and 5 coenzymes

Total MW: 4.5 x 106!

Also present: regulatory protein kinase, phosphatase












Pdh the overall reaction
PDH: The Overall Reaction

  • Acetyl-CoA enter Krebs cycle

  • NADH passes e– to O2


Ketoglutarate dehydrogenase complex
-Ketoglutarate Dehydrogenase Complex

∆Gº= –33.5 kJ/mol


Ketoglutarate dehydrogenase complex1
-Ketoglutarate Dehydrogenase Complex

  • Cofactors: FAD, NAD+, lipoate, TPP, CoASH

  • Mechanism  PDH complex


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