Pyruvate Oxidation Pyruvate dehydrogenase complex. Aerobic Fate of Pyruvate: Overview. Mitochondria: Site of Oxidations. Pyruvate Oxidation to Acetyl-CoA. Pyruvate Dehydrogenase Complex. Complex enzyme 60 polypeptides of 3 kinds In mitocondrion matrix Regulated Inhibited by NADH and GTP
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Total MW: 4.5 x 106!
Also present: regulatory protein kinase, phosphatase
∆Gº= –33.5 kJ/mol