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VectorBase. Invertebrate Vectors of Human Pathogens . Lots of data out there… Data on : Distribution of vectors and their ecology Insecticide resistance Transmission capacity For diseases : Malaria , Chagas , Dengue, Lymph. filariasis , etc. Projects funded by :

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Vectorbase

VectorBase

Invertebrate Vectors of Human Pathogens


Vectorbase

  • Lots of data out there…

  • Data on:

  • Distribution of vectors and their ecology

  • Insecticide resistance

  • Transmission capacity

  • For diseases:

  • Malaria, Chagas, Dengue, Lymph. filariasis, etc.

  • Projects funded by:

  • Innovative Vector Control Consortium - IVCC

  • The WHO/Gates Foundation Vector Biology and Control Project - VBC

  • African Network on Vector Research - ANVR

  • Marathon Oil (and other private investors)

  • And several more, including national programmes

  • Problems:

  • Fragmentation of data; Secrecy; Independence; “Dialects” and syntax; etc.


Vectorbase

The answer, is...

Intelligent Databases

Open access

Decision Support Systems

Interoperability

Efficient searches


Vectorbase

3610 (2392 unique)


Vectorbase

IRBase


Vectorbase

The example of Insecticide Resistance:

Aedes aegypti, 2098 records


Vectorbase

The example of Insecticide Resistance:

Aedes aegypti, 2098 records


Vectorbase

The example of Insecticide Resistance:

Aedes aegypti - DDT, 133 records


Vectorbase

The example of Insecticide Resistance:

Anopheles gambiae, 771 records


Vectorbase

The example of Insecticide Resistance:

A. gambiae - DDT, 198 records


Vectorbase

The example of Insecticide Resistance:

A. gambiae - permethrin, 190 records


Vectorbase

is_a

participates_in

MIRO: resistance assay

CHEBI: insecticide

OBI/MIRO: assay

IDOMAL: Transmission detection assay

is_a

has_output

is_a

MIRO: resistance

PATO: Phenotype

has_input

has_output

has_quality

MIRO: Organism

VB_CV: genotype

IDOMAL:

Human biting rate

Sporozoite rate

Parous rate

Vectorial capacity

IDOMAL: Human population

has_member

VB_CV/MIRO: Mosquito population

Season +

Geolocation +

Human population +

Mosq. population

located_in

has_output

is_a

GAZ: Geolocation

OBI/MIRO: collection assay

is_a

has_quality

is_about

has_input

ENVO : Environmental conditions

e.g.

Rice field,

Irrigation scheme,

swamp,

altitude,

av. temperature,

annual rainfall,

av. humidity

GAZ:

Country,

Province,

District,

GPS coordinates

IDOMAL:

Season

IDOMAL: Malaria control measures


Vectorbase

is_a

participates_in

MIRO: resistance assay

CHEBI: insecticide

OBI/MIRO: assay

IDOMAL: Transmission detection assay

is_a

has_output

is_a

MIRO: resistance

PATO: Phenotype

has_input

has_output

has_quality

MIRO: Organism

VB_CV: genotype

IDOMAL:

Human biting rate

Sporozoite rate

Parous rate

Vectorial capacity

IDOMAL: Human population

has_member

VB_CV/MIRO: Mosquito population

Season +

Geolocation +

Human population +

Mosq. population

located_in

has_output

is_a

GAZ: Geolocation

OBI/MIRO: collection assay

is_a

has_quality

is_about

has_input

ENVO : Environmental conditions

e.g.

Rice field,

Irrigation scheme,

swamp,

altitude,

av. temperature,

annual rainfall,

av. humidity

GAZ:

Country,

Province,

District,

GPS coordinates

IDOMAL:

Season

IDOMAL: Malaria control measures


Vectorbase

is_a

participates_in

"VIRO": resistance assay

CHEBI: insecticide

OBI/"VIRO": assay

"IDOVBD": Transmission detection assay

is_a

has_output

is_a

"VIRO": resistance

PATO: Phenotype

has_input

has_output

has_quality

"VIRO": Organism

VB_CV: genotype

"IDOVBD":

Transmission data relating to vectors of other vector-borne diseases

"VIRO": Human population

has_member

VB_CV/"VIRO": Vectorpopulation

Season +

Geolocation +

Human population +

Vector population

located_in

has_output

is_a

“Oth_Ont1”:

Additional data models

GAZ: Geolocation

OBI/"VIRO": collection assay

is_a

has_quality

is_about

has_input

ENVO : Environmental conditions

e.g.

Rice field,

Irrigation scheme,

swamp,

altitude,

av. temperature,

annual rainfall,

av. humidity

GAZ:

Country,

Province,

District,

GPS coordinates

"IDOVBD": Disease control measures

"IDOVBD":

Season

“Oth_Ont2”:

Additional data models

"IDOVBD":

Additional data models

“VBDbase”


Popgen in vectorbase

PopGen in VectorBase

George Christophides, with Bob MacCallum and Seth Redmont

Kitsos Louis, with Emmanuel Dialynas and PantelisTopalis

A new section of VB being developed that will house data on the population biology of anophelines, as well as data on malaria transmission and IR.


Vectorbase

PATO

IDOMAL

GAZ

UO

Soon to come in VectorBase!

IDOMAL

IDOMAL

VBCV

Linking PopGen and ontologies; Phenotypes, IR,

transmission and popu- lation/ecology data


Vectorbase

  • TGMA – Mosquito Anatomy Ontology; CARO/BFO

  • TADS – Tick Anatomy Ontology; CARO/BFO

  • MIRO – Ontology of Insecticide Resistance; (move) to IDOMAL

  • IDOMAL – Malaria Ontology; IDO/BFO

  • VBCV – Ontology/CV for “completion” of PopGen

  • IDOMAL extension, “IDOChagas”, PLO (Parasite Lifecycle) with PritiParykh, Chris Stoeckertet al.


Vectorbase

LOGICAL THOUGHT IS NOT A PRIVILEGE OF A FEW

IT’S AN OBLIGATION FOR EVERYONE !!!


Vectorbase

Thank you!


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