Focal Segmental Glomerulosclerosis. Sandeep G Huilgol. Introduction. 20% of cases in Children and 40% cses in Adults Progressive glomerular scarring early in the disease course
Sandeep G Huilgol
Perturbation of podocyte attachment to GBM
(α3β1 integrin, dystroglycan, podoplanin)
GBM denudation and collapse of capillary loops
Deposition of hyaline material, adherence to Bowman’s capsule and formation of synechiae
Sclerosis (GBM-like material)
Causes of podocyteinjury
Suspected plasma factors: intact foot processes (or pedicels) along their outer aspect.
Primary : adaptive forms of focal segmental Idiopathic
Secondary adaptive forms of focal segmental
Therapy for SR FSGS after achieving complete remission.
THANK YOU after achieving complete remission.