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Overview Of Geant4 Medical Activities At Hampton UniversityJefferson Lab. Hampton University - Hampton, VA http://www.jlab.org/~gueye/CAMI/cami_web Jefferson Lab - Newport News, VA http://www.jlab.org/glab. Source Uniformity 3D In-vivo Measurements Energy Dependence TeraWatt Lasers

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Overview of geant4 medical activities at hampton universityjefferson lab
Overview Of Geant4 Medical Activities AtHampton UniversityJefferson Lab

Hampton University - Hampton, VA

http://www.jlab.org/~gueye/CAMI/cami_web

Jefferson Lab - Newport News, VA

http://www.jlab.org/glab

  • Source Uniformity

  • 3D In-vivo Measurements

  • Energy Dependence

  • TeraWatt Lasers

  • Electromagnetic Physics

  • Other Research (p-therapy …)

G4NAMU - SLAC 2006


Beta detector coll nist varian
Beta Detector(Coll: NIST, Varian)

→ Uniformity/non-uniformity of sources

→ Absolute calibration of Brachytherapy sources

→ Removed transfer: films ↔ ionization chambers

→ Accuracy better than 100 μm (possibly: 50 μm)

PhD Thesis: Lawrence Tynes

Sr/Y-90

Preliminary

Before

After

Deconvolve

Physics Processes

Data: 03/07/06

G4NAMU - SLAC 2006


Gesib coll mgh laval mcgill varian

z

y

  • Air Bubbles: 20-80 m

  • Medical Physics Parameters

  • Dose Rate

  • Anisotropic Function

  • Radial Dose Function

  • Monte Carlo Codes

  • General Particle Source (GPS)

  • Gaussian/Fermi/… Distributions

  • Density (water/air - 200 m layer)

GESiB (Coll: MGH, Laval, McGill, Varian)

Uniformity/non uniformity

Of Brachytherapy Sources

P-32: Φ=0.21 mm x L=20 mm

Cylinders: number=100,wall =0.2 mm

AAPM: TG43/60, Dose rate @ surface & 2 mm

IAEA: %deviation from average (Req: <20%)

PhD Thesis: Nnenna Onumah

  • Results for 80 m

  • 5% effect on all parameters

  • GPS/G (dE/dx): up to a factor of 2

    modifications in all parameters

  • Patient density (dE/dx):

  • 10% (up to ~0.5 mm) - preliminary

G4NAMU - SLAC 2006


In vivo dose measurements coll depaul hospital varian

XY Dependence

Z Dependence

In-vivo DoseMeasurements (Coll: DePaul Hospital, Varian)

XYZ Dependence

→ Real Time Measurements

→ Position, dose distribution

→ Treatment Plans:

Verification, Adjustments

PhD Thesis: Carlos Velasco

Data: 03/07/06

G4NAMU - SLAC 2006


Active mammosite coll proxima therapeutics depaul hospital
Active Mammosite(Coll: Proxima Therapeutics, dePaul Hospital)

→ Real time measurements

→ Absolute position (≤ ±1 mm)

→ Absolute dose distribution

BSc (MSU): Jacquelyn Winston

BSc (HU): Thomas Cudjoe

Data: 03/07/06

HDR Source

G4NAMU - SLAC 2006


Mono energetic brachytherapy sources coll jefferson lab evms odu

→ Energy dependence of cancer cells

Master Thesis: Ariano Munden (qualitative)

PhD Thesis: Rachel Black (high energy)

PhD Thesis: Yuriy Prilepskiy (low energy)

Mono EnergeticBrachytherapy Sources(Coll: Jefferson Lab, EVMS, ODU)

Breast cancer cells

Dipole

0.3-1 MeV

Collimator & source (Sr-90)

1-2 MeV

New Data Sets: 03/07/06

AIP (2006 APS):

Newsletter/Nature/Science

G4NAMU - SLAC 2006


Advanced laser light source ultrafast interface biology medecine
Advanced Laser Light SourceUltrafast & Interface Biology/Medecine

10 Hz, 300 mJ, 25 fs

  • Varennes, Canada

  • Dynamic of biological processes

  • Radiation safety (monitoring program)

  • Charged beams characterization

  • Medical Applications

100 Hz, 100 mJ, 25 fs

G4NAMU - SLAC 2006


Electromagnetic physics in geant4
Electromagnetic Physics In Geant4

208Pb(e,e’) - E = 100 MeV

~40% effect!

  • Experimental cross sections

    • JLab, NIST: 20 eV to 60 MeV

    • Unpolarized & Polarized Data

    • JLab Mott polarimeter runs

      Period: 1996-2006

      Kinematics: 100 keV & 5 MeV – 173o

      Targets: Au, Cu, Al

    • New scattering chamber

      Fall 2006, angular distribution

      New detectors

      PhD Thesis: Michael Epps

  • Theoretical understanding

    • Coulomb corrections

    • University of Basel & INFN

    • Results by Summer 2006

G4NAMU - SLAC 2006


Other research
Other Research

p

Proton therapy

New HU Center

  • Construction: summer 2006

  • First beam: ~2009

  • Collaboration with MGH, Saclay & Orsay

  • Shielding calculation with Geant4

    Postdoc: Vahagn Nazaryan

    Polarized beams in cancer treatments

    Jefferson Lab electron beam

    DePaul Linac for electron and photon beams

    PhD Thesis: Nanda Karthik

    Kaon therapy

    PhD Thesis:Solomon Sahle

    Convolution product & Lyapunov stability

    (Switzerland/France/Italy/Armenia)

  • Nuclear Physics form factors (validation)

  • Implementation in medical physics

    BS: Leslie Upton

K+

π+

Preliminary

Same depth = 28.5 cm

Medium = water

G4NAMU - SLAC 2006


Questions
! Questions !

G4NAMU - SLAC 2006


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