'Www ebi' presentation slideshows

Enzyme Evolution

Enzyme Evolution. John Mitchell, February 2010. Theories of Enzyme Evolution. Overview. (1) Divergent retrograde evolution, recruiting adjacent enzymes in pathway and constrained by binding similar molecules as substrates or products. Overview.

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ArrayExpress and Gene Expression Atlas:

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Chemical Data and Computer-Aided Drug Discovery

Chemical Data and Computer-Aided Drug Discovery. Mike Gilson School of Pharmacy mgilson@ucsd.edu 2-0622. Outline. Overview of drug discovery Structure-based computational methods When we know the structure of the targeted protein Ligand-based computational methods

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Tutorial: Bioinformatics Resources

Tutorial: Bioinformatics Resources. ( http://pir.georgetown.edu/pirwww/workshop/bioinfo_resource.html ). Bio-Trac 25 (Proteomics: Principles and Methods) October 3, 2008 Zhang-Zhi Hu, M.D. Research Associate Professor Protein Information Resource, Department of

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Gene finding and gene structure prediction

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Measuring transcriptomes with RNA-Seq

Measuring transcriptomes with RNA-Seq. BMI 877 Spring 2014 Colin Dewey cdewey@biostat.wisc.edu. Overview. Some motivation: axolotl RNA-Seq technology The RNA-Seq quantification problem Generative probabilistic models and Expectation-Maximization for the quantification task.

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Sequencing & Sequence Alignment

Sequencing & Sequence Alignment. Objectives. Understand how DNA sequence data is collected and prepared Be aware of the importance of sequence searching and sequence alignment in biology and medicine

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Intro to Next Generation Sequencing

Intro to Next Generation Sequencing. Nick Loman and James Hadfield. http:// omicsmaps.com /. Koboldt et al., 2010 (Figure 3). Bench work to build libraries and sequence. Clean up and QA reads. Alignments to Genome or Transcriptome. Analysis of Alignments. Koboldt et al., 2010.

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Proteomics

Proteomics. Jen,Mona & Krishna. Introduction. What is proteome? proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system at particular time and conditions.

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A Sequence Retrieving and Manipulation Network

Databases. Softwares. Retrival System. Information. Formats. A Sequence Retrieving and Manipulation Network. DNA Protein NCBI-GenBANK PIR DDBJ SWISSPROT EBI-EMBL EXPASY, PDB. GCG SeqWEB Vector NTI GenoMAX. Entrez SRS. GenBANK GCG FASTA Staden Image. Sequence Converter.

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Genome Related Biological Databases

Genome Related Biological Databases. Content. DNA Sequence databases Protein databases Gene prediction Accession numbers NCBI website Ensembl website. Nucleotide databases. The underlying raw DNA sequences are identical. DDBJ. EMBL. GenBank. Housed at EBI European

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Computational analysis of PromoterS

Computational analysis of PromoterS. Gene regulation. Genomes usually contain several thousands of different genes . Some of the gene products are required by the cell under all growth conditions and are called housekeeping genes .

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Phylogenetic Inference

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Drug Design / drug discovery

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Sequence Retrieving, Manipulation and Management

BIOINFORMATICS. Lecture 3. Sequence Retrieving, Manipulation and Management. Databases. Softwares. Retrival System. Information. Formats. A Sequence Retrieving and Manipulation Network. DNA Protein NCBI-GenBANK PIR DDBJ SWISSPROT EBI-EMBL EXPASY, PDB. GCG SeqWEB Vector NTI

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Metabolomics

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A*CHIEVE Questioning in Diagnostic Marking

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Use of assessment to improve student progress

Use of assessment to improve student progress. Miss J Slevin Assistant Head Teaching and Learning RGS. Why :. Ensuring there was a greater consistency in amount of feedback Ensuring there was a greater consistency in the quality of feedback Increase use of peer/self assessment

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Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well?

cytoskeleton/extracellular matrix. extracellular/intracellular communications. proteins/enzymes. hemostasis/thrombosis. nutrition. bioenergetics/metabolism. informational macromolecules. Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well?.

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