'Test drug' presentation slideshows

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Clinical Study Report

Clinical Study Report. Sita Iyer. What is Report. It is a document that summarizes all the incidences and facts that occurred at a given point of time, places or situation. Guidelines. E3 CTD Canadian USFDA Requirement TGA. Summary of these guidelines.

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Pharmacoenvironmentology Current Research Tool in Pharmacovigilance

Pharmacoenvironmentology Current Research Tool in Pharmacovigilance. Syed Ziaur Rahman, MD Assistant Professor Dept. of Pharmacology Jawaharlal Nehru Medical College, AMU, Aligarh, India PhD Candidate School of Medicine University of Western Sydney, Australia. Introduction. INTRODUCTION.

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DRUG DEVELOPMENT AND CONTROL Chapter 2 Dr. Dipa Brahmbhatt VMD MpH Ms dbrahmbh@yahoo

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A New Statin Drug: A Brief History of My Career

A New Statin Drug: A Brief History of My Career. Bonny Ornatowski, Ph.D. GeNetics Pharmaceuticals Cambridge, Massachusetts. Educational Background. B.S. in Chemistry from Temple University, 1982 Ph.D. in Biochemistry from Bryn Mawr College, 1987

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Mastering Stem Cells

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GADA Quarterly Meeting July 16, 2009

GADA Quarterly Meeting July 16, 2009 . Dr. Ken Harshman, Director Division of Generic Animal Drugs. Bioequivalence Data Submissions. Required components: Signed Report: Study Director, Sponsor, QA Study report Index Paginated Appendices Copy of protocol Study data Statistical analysis

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Hepatoprotective and in vivo antioxidant effects of aromatic acetals against CCl4 - induced liver damage in rats

Hepatoprotective activity of the p-methoxy benzaldehyde di-n-butyl acetal and p-nitro benzaldehyde di-n-butyl acetal were investigated using rats with CCl4-induced liver damage. The different groups of animals were administered with carbon tetrachloride (CCl4). The acetals at the dose of 10 ml kg-1 and silymarin 25 mg kg-1 were administered to the CCl4 treated rats. The effect of acetals and silymarin on antioxidant enzymes like superoxide dismutase [SOD], catalase [CAT], glutathione peroxidise [GPX] and thiobarbitutric acid [TBARS] were assayed. The serum enzymes like aspartese aminotransferase [AST], alanine aspartese aminotransferase [ALT], alkaline phosphatase [ALP] and acid phosphatase [ACP] were determined in the rats induced hapatotoxicity by CCl4 to measure liver damage. The acetals and silymarin produced significant (p<0.001) hepatoprotective effect by decreasing the activity of serum enzymes and bilirubin. Specific biochemical parameters were estimated in blood and in liver homogenate. Histopathological examinations of the liver were undertaken to monitor the liver status. From the results, it was suggested that acetals possess potent hepatoprotective and antioxidant properties.

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