'Segmental duplications' presentation slideshows

1.41k views • 129 slides

1.43k views • 129 slides

Genomic Duplications, Structural Variation and Disease

Genomic Duplications, Structural Variation and Disease. Evan Eichler Howard Hughes Medical Institute University of Washington. April 3 rd ,2006, Frontiers in Genomics. Genomic Variation. Mutational mechanisms underlying genetic variation?. Sequence.

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Genome Evolution in Yeast

27 th January 2009 | European Course on. Genome Evolution in Yeast. Gilles Fischer. INTRODUCTION: Comparative genomics Yeasts as model organisms GENOME EVOLUTION: DNA duplications Chromosome dynamics Nucleotide composition. A brief introduction to the field of Comparative Genomics.

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Repetitive elements

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Polymorphic segmental duplications in the nematode Caenorhabditis elegans

Polymorphic segmental duplications in the nematode Caenorhabditis elegans. Ismael Vergara Chen Lab Thursday February 12 th , 2009. Simon Fraser University Department of Molecular Biology and Biochemistry Vancouver Bioinformatics Users Group (VanBUG). Introduction.

495 views • 34 slides

Genome Assembly and Annotation

Genome Assembly and Annotation. Erik Arner Omics Science Center, RIKEN Yokohama, Japan arner@gsc.riken.jp. NCBI Map Viewer. NCBI Map Viewer. Entrez Gene. Entrez Gene. Entrez Gene. Entrez Gene. Aims of lecture. How was the human genome put together Limitations

555 views • 33 slides

The Human Genome and its Dynamics

The Human Genome and its Dynamics. Matthias Platzer Genome Analysis Leibniz Institute for Age Research - Fritz-Lipman n Institute (FLI). Genetic variation Lexicon. Scherer et al. , Nat Genet Suppl 39 :s7 200 7. Genetic variation Terminology. Mutation

500 views • 32 slides

02_13.jpg

Human chromosome 4. 02_13.jpg. 02_15.jpg. 02_15_2.jpg. 1:10,000. 02_03.jpg. Human chromosome 17. 1:6. 1:36. Chromosome specific duplication. Known as L ow C opy R epeat sequences ( LCRs ). Mechanism: Non-Allelic Homologous Recombination ( NAHR ). Eichler, TIGs 17(11) p661, 2001.

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Evolution and diversification of duplicated genes in Laccaria bicolor

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Commentary

Commentary. Do not get too worried about "methods" and details. I fully expect there to be concepts and techniques that you simply are not going to know. Try to figure out the "big picture." Finding papers (from campus you will have access to a lot more journals)

488 views • 27 slides

families with >5 genes are more common in plants than in animals

adapted from Lockton S, Gaut BS. 2005. Trends Genet 21: 60-65. families with >5 genes are more common in plants than in animals. Arabidopsis and rice AS.

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John CK Barber [1,2,3], Shuwen Huang [1], Viv K Maloney [1], John A Crolla [1,2,3].

Transmitted imbalances without phenotypic effect; new examples detected with oligonucleotide array CGH (oaCGH). Association for Clinical Cytogenetics. John CK Barber [1,2,3], Shuwen Huang [1], Viv K Maloney [1], John A Crolla [1,2,3].

348 views • 19 slides

Analyzing Copy Number Variation in the Human Genome

Jeff Bailey S5-432. Analyzing Copy Number Variation in the Human Genome. Continuum of Genomic Variation. Forms of genetic variation. Nucleotide. Single base-pair changes Point mutations (1 per 800 bp) Small insertions/deletions Frameshift, microsatellite, minisatellite Mobile elements

846 views • 19 slides

Global Variation in Copy Number in the Human Genome

Presentation by Chris Wescott and Angelica Stamegna. Global Variation in Copy Number in the Human Genome. Purpose. We, as humans, are 99.5% similar in our genetic make up 1 in 1,000 bp different Used the dissimilarities across populations, to come up with a whole genome CNV map

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Low Copy Repeats in the Human Genome Implications for Genomic Structure

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Primate segmental duplications

Primate segmental duplications. Nature (2006)7:552-564.

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Assays for Detection of Structural Variation

Assays for Detection of Structural Variation. Lampros Mavrogiannis (Newcastle 13/12/2007). Few Definitions. Operational classification of genomic variation. Positional (sequence level <~1kb) Epigenetic (methylation status) Structural (>~1kb) microscopic (>~3Mb)

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Sequence Gaps

Chromosome 17. Oligo Results. Sequence Gaps. Segmental Duplications. BAC Clones. Oligo Probes. RefSeq Genes. SGL GPS.

119 views • 1 slides